Jatin Narula
Jatin Narula
Pfizer Inc., Cambridge MA
بريد إلكتروني تم التحقق منه على pfizer.com
عنوان
عدد مرات الاقتباسات
عدد مرات الاقتباسات
السنة
Chromosomal arrangement of phosphorelay genes couples sporulation and DNA replication
J Narula, A Kuchina, DL Dong-yeon, M Fujita, GM Süel, OA Igoshin
Cell 162 (2), 328-337, 2015
672015
Bistable responses in bacterial genetic networks: designs and dynamical consequences
A Tiwari, JCJ Ray, J Narula, OA Igoshin
Mathematical biosciences 231 (1), 76-89, 2011
652011
Modeling reveals bistability and low-pass filtering in the network module determining blood stem cell fate
J Narula, AM Smith, B Gottgens, OA Igoshin
PLoS Comput Biol 6 (5), e1000771, 2010
652010
Ultrasensitivity of the Bacillus subtilis sporulation decision
J Narula, SN Devi, M Fujita, OA Igoshin
Proceedings of the National Academy of Sciences 109 (50), E3513-E3522, 2012
622012
Impaired angiogenesis in aging myocardial microvascular endothelial cells is associated with reduced importin alpha and decreased nuclear transport of HIF1 alpha: mechanistic …
A Ahluwalia, J Narula, MK Jones, X Deng, AS Tarnawski
Journal of physiology and pharmacology: an official journal of the Polish …, 2010
452010
Triggering sporulation in Bacillus subtilis with artificial two‐component systems reveals the importance of proper Spo0A activation dynamics
M Vishnoi, J Narula, SN Devi, HA Dao, OA Igoshin, M Fujita
Molecular microbiology 90 (1), 181-194, 2013
372013
Maximum entropy production allows a simple representation of heterogeneity in semiarid ecosystems
SJ Schymanski, A Kleidon, M Stieglitz, J Narula
Philosophical Transactions of the Royal Society B: Biological Sciences 365 …, 2010
352010
Mathematical model of a gene regulatory network reconciles effects of genetic perturbations on hematopoietic stem cell emergence
J Narula, CJ Williams, A Tiwari, J Marks-Bluth, JE Pimanda, OA Igoshin
Developmental biology 379 (2), 258-269, 2013
222013
Slowdown of growth controls cellular differentiation
J Narula, A Kuchina, F Zhang, M Fujita, GM Süel, OA Igoshin
Molecular systems biology 12 (5), 871, 2016
182016
Functional requirements of cellular differentiation: lessons from Bacillus subtilis
J Narula, M Fujita, OA Igoshin
Current opinion in microbiology 34, 38-46, 2016
162016
Thermodynamic models of combinatorial gene regulation by distant enhancers
J Narula, OA Igoshin
IET systems biology 4 (6), 393-408, 2010
142010
Role of autoregulation and relative synthesis of operon partners in alternative sigma factor networks
J Narula, A Tiwari, OA Igoshin
PLoS computational biology 12 (12), e1005267, 2016
52016
A quantitative systems pharmacology consortium approach to managing immunogenicity of therapeutic proteins
AM Kierzek, TP Hickling, I Figueroa, JC Kalvass, M Nijsen, K Mohan, ...
CPT: pharmacometrics & systems pharmacology 8 (11), 773-776, 2019
42019
A Novel GUCY2C-CD3 T-Cell Engaging Bispecific Construct (PF-07062119) for the Treatment of Gastrointestinal Cancers
D Mathur, AR Root, B Bugaj-Gaweda, S Bisulco, X Tan, W Fang, ...
Clinical Cancer Research 26 (9), 2188-2202, 2020
12020
Importance of feedback and feedforward loops to adaptive immune response modeling
A Rahman, A Tiwari, J Narula, T Hickling
CPT: pharmacometrics & systems pharmacology 7 (10), 621-628, 2018
12018
Preclinical Evaluation of 89Zr-Df-IAB22M2C PET as a Potential Imaging Biomarker in Targeted Immuno-Therapeutic Drug Development of a GUCY2C-CD3 bispecific antibody PF-07062119.
K Maresca, J Chen, D Mathur, A Giddabasappa, A Root, J Narula, L King, ...
Journal of Nuclear Medicine 61 (supplement 1), 408-408, 2020
2020
A Quantitative Systems Pharmacology Approach for Translational Modeling of AAV8-Based Gene Therapy Products in Rodents, Macaques and Man
J Narula, Z Zhang, GH Ko, M Roy, P Goihberg, LE King, M Pregel, R Bell, ...
MOLECULAR THERAPY 28 (4), 93-94, 2020
2020
Abstract A16: A GUCY2c-CD3 bispecific engages T cells to induce cytotoxicity in gastrointestinal tumors
D Mathur, A Root, B Bugaj-Gaweda, X Tan, W Fang, S Bisulco, J Golas, ...
Cancer Immunology Research 8 (3 Supplement), A16-A16, 2020
2020
A GUCY2c-CD3 bispecific engages T cells to induce cytotoxicity in gastrointestinal tumors.
D Mathur, A Root, B Bugaj-Gaweda, X Tan, W Fang, S Bisulco, J Golas, ...
CANCER IMMUNOLOGY RESEARCH 8 (3), 38-39, 2020
2020
A semi-mechanistic platform model to capture individual animal responses to checkpoint inhibitors in a syngeneic mouse model
L Lin, A Betts, C Young, W Qiao, J Narula, P O'Brien, D Bartlett, A Hooper, ...
JOURNAL FOR IMMUNOTHERAPY OF CANCER 7, 2019
2019
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مقالات 1–20