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Katherine R. Singleton
Katherine R. Singleton
Biomedical Genetics, University of Rochester
Verified email at urmc.rochester.edu
Title
Cited by
Cited by
Year
A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop
KE Ware, TK Hinz, E Kleczko, KR Singleton, LA Marek, BA Helfrich, ...
Oncogenesis 2 (3), e39-e39, 2013
2502013
Systematic identification of signaling pathways with potential to confer anticancer drug resistance
CA Martz, KA Ottina, KR Singleton, JS Jasper, SE Wardell, ...
Science signaling 7 (357), ra121-ra121, 2014
2182014
Fibroblast growth factor receptors are components of autocrine signaling networks in head and neck squamous cell carcinoma cells
ME Marshall, TK Hinz, SA Kono, KR Singleton, B Bichon, KE Ware, ...
Clinical cancer research 17 (15), 5016-5025, 2011
1152011
Melanoma therapeutic strategies that select against resistance by exploiting MYC-driven evolutionary convergence
KR Singleton, L Crawford, E Tsui, HE Manchester, O Maertens, X Liu, ...
Cell reports 21 (10), 2796-2812, 2017
952017
Kinome RNAi screens reveal synergistic targeting of MTOR and FGFR1 pathways for treatment of lung cancer and HNSCC
KR Singleton, TK Hinz, EK Kleczko, LA Marek, J Kwak, T Harp, J Kim, ...
Cancer research 75 (20), 4398-4406, 2015
632015
Using antagonistic pleiotropy to design a chemotherapy-induced evolutionary trap to target drug resistance in cancer
KH Lin, JC Rutter, A Xie, B Pardieu, ET Winn, RD Bello, A Forget, ...
Nature genetics 52 (4), 408-417, 2020
542020
A receptor tyrosine kinase network composed of fibroblast growth factor receptors, epidermal growth factor receptor, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 …
KR Singleton, J Kim, TK Hinz, LA Marek, M Casás-Selves, C Hatheway, ...
Molecular pharmacology 83 (4), 882-893, 2013
482013
Elevated extracellular K+ inhibits apoptosis of corneal epithelial cells exposed to UV-B radiation
KR Singleton, DS Will, MP Schotanus, LD Haarsma, LR Koetje, ...
Experimental eye research 89 (2), 140-151, 2009
292009
Bioinformatics-driven discovery of rational combination for overcoming EGFR-mutant lung cancer resistance to EGFR therapy
J Kim, VT Vasu, R Mishra, KR Singleton, M Yoo, SM Leach, ...
Bioinformatics 30 (17), 2393-2398, 2014
272014
ALK is a critical regulator of the MYC-signaling axis in ALK positive lung cancer
AB Pilling, J Kim, A Estrada-Bernal, Q Zhou, AT Le, KR Singleton, ...
Oncotarget 9 (10), 8823, 2018
232018
Evolved resistance to partial GAPDH inhibition results in loss of the Warburg effect and in a different state of glycolysis
MV Liberti, AE Allen, V Ramesh, Z Dai, KR Singleton, Z Guo, JO Liu, ...
Journal of Biological Chemistry 295 (1), 111-124, 2020
142020
An inducible TGF-β2-TGFβR pathway modulates the sensitivity of HNSCC cells to tyrosine kinase inhibitors targeting dominant receptor tyrosine kinases
EK Kleczko, J Kim, SB Keysar, LR Heasley, JR Eagles, M Simon, ...
PLoS One 10 (5), e0123600, 2015
122015
Discrete-time term structure models with generalized market prices of risk
Q Dai, A Le, KJ Singleton
working paper, 2006
102006
Functional RNAi screens define distinct protein kinase vulnerabilities in EGFR-dependent HNSCC cell lines
TK Hinz, EK Kleczko, KR Singleton, J Calhoun, LA Marek, J Kim, AC Tan, ...
Molecular Pharmacology 96 (6), 862-870, 2019
72019
Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes
KR Singleton, KC Wood
Genes & Cancer 7 (7-8), 218, 2016
62016
Drug dependence in cancer is exploitable by optimally constructed treatment holidays
J Maltas, ST Killarney, KR Singleton, MAR Strobl, R Washart, KC Wood, ...
Nature Ecology & Evolution 8 (1), 147-162, 2024
52024
Analysis of drug resistance using kinome-wide functional screens
KR Singleton, KT Earley, LE Heasley
Kinase Signaling Networks, 163-177, 2017
32017
A Receptor Tyrosine Kinase Network Comprised of FGFRs, EGFR, ERBB2 and MET Drives Growth and Survival of Head and Neck Squamous Carcinoma Cell Lines
KR Singleton, J Kim, TK Hinz, LA Marek, M Casas-Selves, C Hatheway, ...
Molecular Pharmacology, 2013
32013
Evolved resistance to GAPDH inhibition results in loss of the Warburg Effect but retains a different state of glycolysis
MV Liberti, AE Allen, V Ramesh, Z Dai, KR Singleton, Z Guo, JO Liu, ...
bioRxiv, 602557, 2019
12019
ALK-driven lung cancer: potential therapeutic strategies for treatment and prevention of drug resistance
AB Pilling, AT Le, AC Tan, J Kim, KR Singleton, LE Heasley, B Helfrich, ...
Cancer Research 72 (8_Supplement), 5594-5594, 2012
12012
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Articles 1–20