The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit SL Spencer, SD Cappell, FC Tsai, KW Overton, CL Wang, T Meyer Cell 155 (2), 369-383, 2013 | 686 | 2013 |
Irreversible APCCdh1 inactivation underlies the point of no return for cell-cycle entry SD Cappell, M Chung, A Jaimovich, SL Spencer, T Meyer Cell 166 (1), 167-180, 2016 | 248 | 2016 |
EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle SD Cappell, KG Mark, D Garbett, LR Pack, M Rape, T Meyer Nature 558 (7709), 313-317, 2018 | 135 | 2018 |
Regulators of G-protein signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity NA Lambert, CA Johnston, SD Cappell, S Kuravi, AJ Kimple, FS Willard, ... Proceedings of the National Academy of Sciences 107 (15), 7066-7071, 2010 | 105 | 2010 |
Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor‐mediated differentiation MD Willard, FS Willard, X Li, SD Cappell, WD Snider, DP Siderovski The EMBO journal 26 (8), 2029-2040, 2007 | 97 | 2007 |
Transient hysteresis in CDK4/6 activity underlies passage of the restriction point in G1 M Chung, C Liu, HW Yang, MS Köberlin, SD Cappell, T Meyer Molecular cell 76 (4), 562-573. e4, 2019 | 92 | 2019 |
Stress-mediated exit to quiescence restricted by increasing persistence in CDK4/6 activation HW Yang, SD Cappell, A Jaimovich, C Liu, M Chung, LH Daigh, LR Pack, ... Elife 9, e44571, 2020 | 68 | 2020 |
Systematic analysis of essential genes reveals important regulators of G protein signaling SD Cappell, R Baker, D Skowyra, HG Dohlman Molecular cell 38 (5), 746-757, 2010 | 45 | 2010 |
Loss of CDK4/6 activity in S/G2 phase leads to cell cycle reversal JA Cornwell, A Crncec, MM Afifi, K Tang, R Amin, SD Cappell Nature 619 (7969), 363-370, 2023 | 36 | 2023 |
Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response R Amin, A Shukla, JJ Zhu, S Kim, P Wang, SZ Tian, AD Tran, D Paul, ... Nature Communications 12 (1), 7216, 2021 | 34 | 2021 |
Cell cycle-dependent phosphorylation and ubiquitination of a G protein α subunit MP Torres, ST Clement, SD Cappell, HG Dohlman Journal of Biological Chemistry 286 (23), 20208-20216, 2011 | 33 | 2011 |
Cell cycle inertia underlies a bifurcation in cell fates after DNA damage JF Nathans, JA Cornwell, MM Afifi, D Paul, SD Cappell Science advances 7 (3), eabe3882, 2021 | 25 | 2021 |
Selective regulation of MAP kinase signaling by an endomembrane phosphatidylinositol 4-kinase SD Cappell, HG Dohlman Journal of Biological Chemistry 286 (17), 14852-14860, 2011 | 25 | 2011 |
Apoptosis-induced nuclear expulsion in tumor cells drives S100a4-mediated metastatic outgrowth through the RAGE pathway WY Park, JM Gray, RJ Holewinski, T Andresson, JY So, ... Nature Cancer 4 (3), 419-435, 2023 | 24 | 2023 |
The RepID–CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation SM Jang, JF Nathans, H Fu, CE Redon, LM Jenkins, BL Thakur, ... Nature Communications 11 (1), 24, 2020 | 24 | 2020 |
Estrogen and progesterone lower cyclin B1 AND D1 expression, block cell cycle in G2/M, and trigger apoptosis in human adrenal carcinoma cell cultures JW Brown, LM Prieto, C Perez-Stable, M Montoya, S Cappell, ... Hormone and metabolic research 40 (05), 306-310, 2008 | 22 | 2008 |
Ribosome biogenesis is a downstream effector of the oncogenic U2AF1-S34F mutation A Akef, K McGraw, SD Cappell, DR Larson PLoS biology 18 (11), e3000920, 2020 | 21 | 2020 |
Revealing β-TrCP activity dynamics in live cells with a genetically encoded biosensor D Paul, SC Kales, JA Cornwell, MM Afifi, G Rai, A Zakharov, A Simeonov, ... Nature Communications 13 (1), 6364, 2022 | 14 | 2022 |
Extracts from two marine sponges lower cyclin B1 levels, cause a G2/M cell cycle block and trigger apoptosis in SW-13 human adrenal carcinoma cells JW Brown, S Cappell, C Perez-Stable, LM Fishman Toxicon 43 (7), 841-846, 2004 | 11 | 2004 |
Irreversible cell cycle exit associated with senescence is mediated by constitutive MYC degradation MM Afifi, A Crncec, JA Cornwell, C Cataisson, D Paul, LM Ghorab, ... Cell reports 42 (9), 2023 | 9 | 2023 |