| Host recognition of bacterial muramyl dipeptide mediated through NOD2: implications for Crohn′ s disease N Inohara, Y Ogura, A Fontalba, O Gutierrez, F Pons, J Crespo, K Fukase, ... Journal of Biological Chemistry 278 (8), 5509-5512, 2003 | 2159 | 2003 |
| An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid M Chamaillard, M Hashimoto, Y Horie, J Masumoto, S Qiu, L Saab, ... Nature immunology 4 (7), 702-707, 2003 | 1618 | 2003 |
| Toll-like receptor 4 imparts ligand-specific recognition of bacterial lipopolysaccharide E Lien, TK Means, H Heine, A Yoshimura, S Kusumoto, K Fukase, ... The Journal of clinical investigation 105 (4), 497-504, 2000 | 952 | 2000 |
| A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation M Hasegawa, Y Fujimoto, PC Lucas, H Nakano, K Fukase, G Núñez, ... The EMBO journal 27 (2), 373-383, 2008 | 589 | 2008 |
| Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa U Ohto, K Fukase, K Miyake, Y Satow Science 316 (5831), 1632-1634, 2007 | 543 | 2007 |
| Monomeric and polymeric gram-negative peptidoglycan but not purified LPS stimulate the Drosophila IMD pathway T Kaneko, WE Goldman, P Mellroth, H Steiner, K Fukase, S Kusumoto, ... Immunity 20 (5), 637-649, 2004 | 505 | 2004 |
| Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response SW Montminy, N Khan, S McGrath, MJ Walkowicz, F Sharp, JE Conlon, ... Nature immunology 7 (10), 1066-1073, 2006 | 495 | 2006 |
| Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14 S Akashi, S Saitoh, Y Wakabayashi, T Kikuchi, N Takamura, Y Nagai, ... The Journal of experimental medicine 198 (7), 1035-1042, 2003 | 487 | 2003 |
| Various human epithelial cells express functional Toll-like receptors, NOD1 and NOD2 to produce anti-microbial peptides, but not proinflammatory cytokines A Uehara, Y Fujimoto, K Fukase, H Takada Molecular immunology 44 (12), 3100-3111, 2007 | 440 | 2007 |
| Autophagic control of listeria through intracellular innate immune recognition in drosophila T Yano, S Mita, H Ohmori, Y Oshima, Y Fujimoto, R Ueda, H Takada, ... Nature immunology 9 (8), 908-916, 2008 | 430 | 2008 |
| Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2 U Ohto, K Fukase, K Miyake, T Shimizu Proceedings of the National Academy of Sciences 109 (19), 7421-7426, 2012 | 371 | 2012 |
| Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition S Akashi, Y Nagai, H Ogata, M Oikawa, K Fukase, S Kusumoto, ... International immunology 13 (12), 1595-1599, 2001 | 310 | 2001 |
| Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll‐like receptor 4 (TLR4)‐MD‐2 and ligand‐induced TLR4 oligomerization S Saitoh, S Akashi, T Yamada, N Tanimura, M Kobayashi, K Konno, ... International immunology 16 (7), 961-969, 2004 | 305 | 2004 |
| Aggregates are the biologically active units of endotoxin M Mueller, B Lindner, S Kusumoto, K Fukase, AB Schromm, U Seydel Journal of Biological Chemistry 279 (25), 26307-26313, 2004 | 291 | 2004 |
| Nod1 acts as an intracellular receptor to stimulate chemokine production and neutrophil recruitment in vivo J Masumoto, K Yang, S Varambally, M Hasegawa, SA Tomlins, S Qiu, ... The Journal of experimental medicine 203 (1), 203-213, 2006 | 277 | 2006 |
| Human peptidoglycan recognition protein-L is an N-acetylmuramoyl-L-alanine amidase ZM Wang, X Li, RR Cocklin, M Wang, M Wang, K Fukase, S Inamura, ... Journal of Biological Chemistry 278 (49), 49044-49052, 2003 | 276 | 2003 |
| Muramyldipeptide and diaminopimelic acid‐containing desmuramylpeptides in combination with chemically synthesized Toll‐like receptor agonists synergistically induced production … A Uehara, S Yang, Y Fujimoto, K Fukase, S Kusumoto, K Shibata, ... Cellular microbiology 7 (1), 53-61, 2005 | 271 | 2005 |
| Intrinsic conformation of lipid A is responsible for agonistic and antagonistic activity U Seydel, M Oikawa, K Fukase, S Kusumoto, K Brandenburg European Journal of Biochemistry 267 (10), 3032-3039, 2000 | 263 | 2000 |
| The NLRP6 inflammasome recognizes lipoteichoic acid and regulates gram-positive pathogen infection H Hara, SS Seregin, D Yang, K Fukase, M Chamaillard, ES Alnemri, ... Cell 175 (6), 1651-1664. e14, 2018 | 228 | 2018 |
| Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells JH Park, YG Kim, M Shaw, TD Kanneganti, Y Fujimoto, K Fukase, ... The Journal of Immunology 179 (1), 514-521, 2007 | 220 | 2007 |
