| A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease M Björkqvist, EJ Wild, J Thiele, A Silvestroni, R Andre, N Lahiri, E Raibon, ... Journal of Experimental Medicine 205 (8), 1869-1877, 2008 | 740 | 2008 |
| Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice AJ Milnerwood, CM Gladding, MA Pouladi, AM Kaufman, RM Hines, ... Neuron 65 (2), 178-190, 2010 | 599 | 2010 |
| Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity W Song, J Chen, A Petrilli, G Liot, E Klinglmayr, Y Zhou, P Poquiz, J Tjong, ... Nature medicine 17 (3), 377-382, 2011 | 582 | 2011 |
| Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin S Okamoto*, MA Pouladi*, M Talantova*, D Yao*, P Xia, DE Ehrnhoefer, ... Nature medicine 15 (12), 1407-1413, 2009 | 493 | 2009 |
| Choosing an animal model for the study of Huntington's disease MA Pouladi, AJ Morton, MR Hayden Nature Reviews Neuroscience 14 (10), 708-721, 2013 | 406 | 2013 |
| Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin … A Kuhn, DR Goldstein, A Hodges, AD Strand, T Sengstag, C Kooperberg, ... Human molecular genetics 16 (15), 1845-1861, 2007 | 383 | 2007 |
| Induced-Pluripotent-Stem-Cell-Derived Primitive Macrophages Provide a Platform for Modeling Tissue-Resident Macrophage Differentiation and Function K Takata, T Kozaki, CZW Lee, MS Thion, M Otsuka, S Lim, KH Utami, ... Immunity 47 (1), 183-198. e6, 2017 | 337 | 2017 |
| Cigarette smoke decreases pulmonary dendritic cells and impacts antiviral immune responsiveness CS Robbins, DE Dawe, SI Goncharova, MA Pouladi, AG Drannik, ... American journal of respiratory cell and molecular biology 30 (2), 202-211, 2004 | 263 | 2004 |
| Impact of Cigarette Smoke on Clearance and Inflammation after Pseudomonas aeruginosa Infection AG Drannik, MA Pouladi, CS Robbins, SI Goncharova, S Kianpour, ... American journal of respiratory and critical care medicine 170 (11), 1164-1171, 2004 | 232 | 2004 |
| Reversal of phenotypic abnormalities by CRISPR/Cas9-mediated gene correction in Huntington disease patient-derived induced pluripotent stem cells X Xu, Y Tay, B Sim, SI Yoon, Y Huang, J Ooi, KH Utami, A Ziaei, B Ng, ... Stem cell reports 8 (3), 619-633, 2017 | 213 | 2017 |
| Inhibition of phosphatidylinositol-4-phosphate 5-kinase Iα impairs localized actin remodeling and suppresses phagocytosis MG Coppolino, R Dierckman, J Loijens, RF Collins, M Pouladi, ... Journal of Biological Chemistry 277 (46), 43849-43857, 2002 | 188 | 2002 |
| Prevention of depressive behaviour in the YAC128 mouse model of Huntington disease by mutation at residue 586 of huntingtin MA Pouladi, RK Graham, JM Karasinska, Y Xie, RD Santos, Å Petersén, ... Brain 132 (4), 919-932, 2009 | 182 | 2009 |
| Cholesterol defect is marked across multiple rodent models of Huntington's disease and is manifest in astrocytes M Valenza, V Leoni, JM Karasinska, L Petricca, J Fan, J Carroll, ... Journal of Neuroscience 30 (32), 10844-10850, 2010 | 178 | 2010 |
| Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice MA Pouladi, LM Stanek, Y Xie, S Franciosi, AL Southwell, Y Deng, ... Human molecular genetics 21 (10), 2219-2232, 2012 | 177 | 2012 |
| Modeling Doxorubicin-Induced Cardiotoxicity in Human Pluripotent Stem Cell Derived-Cardiomyocytes A Maillet, K Tan, X Chai, SN Sadananda, A Mehta, J Ooi, MR Hayden, ... Scientific Reports 6, 25333, 2016 | 175 | 2016 |
| A thiol probe for measuring unfolded protein load and proteostasis in cells MZ Chen, NS Moily, JL Bridgford, RJ Wood, M Radwan, TA Smith, Z Song, ... Nature Communications 8 (1), 474, 2017 | 148 | 2017 |
| Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease RK Graham, MA Pouladi, P Joshi, G Lu, Y Deng, NP Wu, BE Figueroa, ... Journal of Neuroscience 29 (7), 2193-2204, 2009 | 142 | 2009 |
| Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo RK Graham, Y Deng, J Carroll, K Vaid, C Cowan, MA Pouladi, M Metzler, ... Journal of Neuroscience 30 (45), 15019-15029, 2010 | 141 | 2010 |
| Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression MA Pouladi, Y Xie, NH Skotte, DE Ehrnhoefer, RK Graham, JE Kim, ... Human molecular genetics 19 (8), 1528-1538, 2010 | 141 | 2010 |
| Mouse models of Huntington disease: variations on a theme DE Ehrnhoefer, SL Butland, MA Pouladi, MR Hayden Disease models & mechanisms 2 (3-4), 123-129, 2009 | 132 | 2009 |
Michael HaydenKillam Professor, University of British ColumbiaVerified email at cmmt.ubc.ca
