A protein catalytic framework with an N-terminal nucleophile is capable of self-activation JA Brannigan, G Dodson, HJ Duggleby, PCE Moody, JL Smith, ... Nature 378 (6555), 416-419, 1995 | 823 | 1995 |
Crystal structure of a DExx box DNA helicase HS Subramanya, LE Bird, JA Brannigan, DB Wigley Nature 384 (6607), 379-383, 1996 | 542 | 1996 |
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. CG Dowson, A Hutchison, JA Brannigan, RC George, D Hansman, ... Proceedings of the National Academy of Sciences 86 (22), 8842-8846, 1989 | 526 | 1989 |
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness JA Frearson, S Brand, SP McElroy, LAT Cleghorn, O Smid, L Stojanovski, ... Nature 464 (7289), 728-732, 2010 | 316 | 2010 |
Protein engineering 20 years on JA Brannigan, AJ Wilkinson Nature Reviews Molecular Cell Biology 3 (12), 964-970, 2002 | 271 | 2002 |
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells E Thinon, RA Serwa, M Broncel, JA Brannigan, U Brassat, MH Wright, ... Nature communications 5 (1), 4919, 2014 | 243 | 2014 |
Recruitment of a penicillin-binding protein gene from Neisseria flavescens during the emergence of penicillin resistance in Neisseria meningitidis. BG Spratt, QY Zhang, DM Jones, A Hutchison, JA Brannigan, CG Dowson Proceedings of the National Academy of Sciences 86 (22), 8988-8992, 1989 | 221 | 1989 |
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach MH Wright, B Clough, MD Rackham, K Rangachari, JA Brannigan, ... Nature chemistry 6 (2), 112-121, 2014 | 213 | 2014 |
Crystal structures of penicillin acylase enzyme-substrate complexes: structural insights into the catalytic mechanism CE McVey, MA Walsh, GG Dodson, KS Wilson, JA Brannigan Journal of molecular biology 313 (1), 139-150, 2001 | 198 | 2001 |
Phosphorylated aspartate in the structure of a response regulator protein RJ Lewis, JA Brannigan, K Muchová, I Barák, AJ Wilkinson Journal of molecular biology 294 (1), 9-15, 1999 | 192 | 1999 |
Structural and functional analysis of a conjugated bile salt hydrolase from Bifidobacterium longum reveals an evolutionary relationship with penicillin V acylase RS Kumar, JA Brannigan, AA Prabhune, AV Pundle, GG Dodson, ... Journal of Biological Chemistry 281 (43), 32516-32525, 2006 | 161 | 2006 |
Pentapeptide regulation of aspartyl-phosphate phosphatases M Perego, JA Brannigan Peptides 22 (10), 1541-1547, 2001 | 148 | 2001 |
Penicillin V acylase crystal structure reveals new Ntn-hydrolase family members CG Suresh, AV Pundle, H SivaRaman, KN Rao, JA Brannigan, CE McVey, ... Nature structural biology 6 (5), 414-416, 1999 | 146 | 1999 |
Insertion of an extra amino acid is the main cause of the low affinity of penicillin‐binding protein 2 in penicillin‐resistant strains of Neisseria gonorrhoeae JA Brannigan, IA Tirodimos, QY Zhang, CG Dowson, BG Spratt Molecular microbiology 4 (6), 913-919, 1990 | 131 | 1990 |
Ligand-induced conformational change in penicillin acylase SH Done, JA Brannigan, PCE Moody, RE Hubbard Journal of molecular biology 284 (2), 463-475, 1998 | 125 | 1998 |
Crystal structure of GerE, the ultimate transcriptional regulator of spore formation in Bacillus subtilis VMA Ducros, RJ Lewis, CS Verma, EJ Dodson, G Leonard, ... Journal of Molecular Biology 306 (4), 759-771, 2001 | 121 | 2001 |
Characterisation of Bacillus stearothermophilus PcrA helicase: Evidence against an active rolling mechanism LE Bird, JA Brannigan, HS Subramanya, DB Wigley Nucleic acids research 26 (11), 2686-2693, 1998 | 121 | 1998 |
An evolutionary link between sporulation and prophage induction in the structure of a repressor: anti-repressor complex RJ Lewis, JA Brannigan, WA Offen, I Smith, AJ Wilkinson Journal of molecular biology 283 (5), 907-912, 1998 | 120 | 1998 |
N-myristoyltransferase from Leishmania donovani: structural and functional characterisation of a potential drug target for visceral leishmaniasis JA Brannigan, BA Smith, Z Yu, AM Brzozowski, MR Hodgkinson, A Maroof, ... Journal of molecular biology 396 (4), 985-999, 2010 | 118 | 2010 |
Water networks can determine the affinity of ligand binding to proteins JF Darby, AP Hopkins, S Shimizu, SM Roberts, JA Brannigan, ... Journal of the American Chemical Society 141 (40), 15818-15826, 2019 | 107 | 2019 |