| MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters BR Terlouw, K Blin, JC Navarro-Muñoz, NE Avalon, MG Chevrette, ... Nucleic acids research 51 (D1), D603-D610, 2023 | 131 | 2023 |
| Strain prioritization and genome mining for enediyne natural products X Yan, H Ge, T Huang, Hindra, D Yang, Q Teng, I Crnovčić, X Li, ... MBio 7 (6), 10.1128/mbio. 02104-16, 2016 | 95 | 2016 |
| Discovery of the leinamycin family of natural products by mining actinobacterial genomes G Pan, Z Xu, Z Guo, Hindra, M Ma, D Yang, H Zhou, Y Gansemans, X Zhu, ... Proceedings of the National Academy of Sciences 114 (52), E11131-E11140, 2017 | 92 | 2017 |
| Enediynes: exploration of microbial genomics to discover new anticancer drug leads B Shen, X Yan, T Huang, H Ge, D Yang, Q Teng, JD Rudolf, JR Lohman Bioorganic & medicinal chemistry letters 25 (1), 9-15, 2015 | 69 | 2015 |
| Strain prioritization for natural product discovery by a high-throughput real-time PCR method Hindra, T Huang, D Yang, JD Rudolf, P Xie, G Xie, Q Teng, JR Lohman, ... Journal of natural products 77 (10), 2296-2303, 2014 | 69 | 2014 |
| Genome Mining of Micromonospora yangpuensis DSM 45577 as a Producer of an Anthraquinone-Fused Enediyne X Yan, JJ Chen, A Adhikari, D Yang, I Crnovcic, N Wang, CY Chang, ... Organic Letters 19 (22), 6192-6195, 2017 | 61 | 2017 |
| Generation of high-yield rapamycin-producing strains through protoplasts-related techniques X Chen, P Wei, L Fan, D Yang, X Zhu, W Shen, Z Xu, P Cen Applied microbiology and biotechnology 83, 507-512, 2009 | 57 | 2009 |
| Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes P Xie, M Ma, ME Rateb, KA Shaaban, Z Yu, SX Huang, LX Zhao, X Zhu, ... Journal of natural products 77 (2), 377-387, 2014 | 55 | 2014 |
| Leinamycin E1 acting as an anticancer prodrug activated by reactive oxygen species SX Huang, BS Yun, M Ma, HS Basu, DR Church, G Ingenhorst, Y Huang, ... Proceedings of the National Academy of Sciences 112 (27), 8278-8283, 2015 | 48 | 2015 |
| A designer bleomycin with significantly improved DNA cleavage activity SX Huang, Z Feng, L Wang, U Galm, E Wendt-Pienkowski, D Yang, M Tao, ... Journal of the American Chemical Society 134 (32), 13501-13509, 2012 | 45 | 2012 |
| Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion M Ma, ME Rateb, Q Teng, D Yang, JD Rudolf, X Zhu, Y Huang, LX Zhao, ... Journal of natural products 78 (10), 2471-2480, 2015 | 40 | 2015 |
| Comparative studies of the biosynthetic gene clusters for anthraquinone-fused enediynes shedding light into the tailoring steps of tiancimycin biosynthesis X Yan, JJ Chen, A Adhikari, CN Teijaro, H Ge, I Crnovcic, CY Chang, ... Organic Letters 20 (18), 5918-5921, 2018 | 39 | 2018 |
| Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234 L Liu, J Pan, Z Wang, X Yan, D Yang, X Zhu, B Shen, Y Duan, Y Huang Journal of Industrial Microbiology and Biotechnology 45 (3), 141-151, 2018 | 37 | 2018 |
| Medium optimization of Streptomyces sp. 17944 for tirandamycin B production and isolation and structural elucidation of tirandamycins H, I and J ME Rateb, Z Yu, Y Yan, D Yang, T Huang, S Vodanovic-Jankovic, ... The Journal of antibiotics 67 (1), 127-132, 2014 | 37 | 2014 |
| Leveraging a large microbial strain collection for natural product discovery AD Steele, CN Teijaro, D Yang, B Shen Journal of Biological Chemistry 294 (45), 16567-16576, 2019 | 34 | 2019 |
| Titer improvement and pilot-scale production of platensimycin from Streptomyces platensis SB12026 J Shi, J Pan, L Liu, D Yang, S Lu, X Zhu, B Shen, Y Duan, Y Huang Journal of Industrial Microbiology and Biotechnology 43 (7), 1027-1035, 2016 | 32 | 2016 |
| Strain improvement by combined UV mutagenesis and ribosome engineering and subsequent fermentation optimization for enhanced 6′-deoxy-bleomycin Z production X Zhu, J Kong, H Yang, R Huang, Y Huang, D Yang, B Shen, Y Duan Applied microbiology and biotechnology 102, 1651-1661, 2018 | 29 | 2018 |
| Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001 L Jiang, H Pu, J Xiang, M Su, X Yan, D Yang, X Zhu, B Shen, Y Duan, ... Frontiers in Chemistry 6, 254, 2018 | 27 | 2018 |
| The discovery and development of microbial bleomycin analogues J Kong, L Yi, Y Xiong, Y Huang, D Yang, X Yan, B Shen, Y Duan, X Zhu Applied microbiology and biotechnology 102, 6791-6798, 2018 | 24 | 2018 |
| Resistance to enediyne antitumor antibiotics by sequestration CY Chang, X Yan, I Crnovcic, T Annaval, C Chang, B Nocek, JD Rudolf, ... Cell chemical biology 25 (9), 1075-1085. e4, 2018 | 23 | 2018 |
Ben ShenThe Scripps Research InstituteVerified email at scripps.edu
