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Owen Siggs
Owen Siggs
Verified email at garvan.org.au
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Cited by
Year
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
D Mérino, M Giam, PD Hughes, OM Siggs, K Heger, LA O'Reilly, ...
Journal Of Cell Biology 186 (3), 355-362, 2009
2302009
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries
P Gharahkhani, E Jorgenson, P Hysi, AP Khawaja, S Pendergrass, X Han, ...
Nature communications 12 (1), 1258, 2021
2192021
Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression
JE Craig, X Han, A Qassim, M Hassall, JNC Bailey, TG Kinzy, AP Khawaja, ...
Nature Genetics, 1-7, 2020
2162020
Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity
T Souma, SW Tompson, BR Thomson, OM Siggs, K Kizhatil, S Yamaguchi, ...
Journal of clinical investigation 126 (7), 2575-2587, 2016
1852016
Genome-wide association study of intraocular pressure uncovers new pathways to glaucoma
S MacGregor, JS Ong, J An, X Han, T Zhou, OM Siggs, MH Law, ...
Nature genetics 50 (8), 1067-1071, 2018
1642018
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
K Brandl, L Sun, C Neppl, OM Siggs, SM Le Gall, W Tomisato, X Li, X Du, ...
Proceedings of the National Academy of Sciences 107 (46), 19967-19972, 2010
1632010
Unravelling the association of partial T-cell immunodeficiency and immune dysregulation
A Liston, A Enders, OM Siggs
Nature Reviews Immunology 8 (7), 545-558, 2008
1552008
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
OM Siggs, LA Miosge, AL Yates, EM Kucharska, D Sheahan, T Brdicka, ...
Immunity 27 (6), 912-926, 2007
1482007
The BTB-ZF transcription factors
OM Siggs, B Beutler
Cell cycle 11 (18), 3358-3369, 2012
1332012
The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow
OM Siggs, CN Arnold, C Huber, E Pirie, Y Xia, P Lin, D Nemazee, ...
Nature immunology 12 (5), 434-440, 2011
1052011
iRhom2 is required for the secretion of mouse TNFα
OM Siggs, N Xiao, Y Wang, H Shi, W Tomisato, X Li, Y Xia, B Beutler
Blood, The Journal of the American Society of Hematology 119 (24), 5769-5771, 2012
1032012
The why and how of thymocyte negative selection
OM Siggs, LE Makaroff, A Liston
Current opinion in immunology 18 (2), 175-183, 2006
1022006
A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity
CN Arnold, E Pirie, P Dosenovic, GM McInerney, Y Xia, N Wang, X Li, ...
Proceedings of the National Academy of Sciences 109 (31), 12286-12293, 2012
1002012
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
M Berger, P Krebs, K Crozat, X Li, BA Croker, OM Siggs, D Popkin, X Du, ...
Nature immunology 11 (4), 335-343, 2010
992010
Copy number variations of TBK1 in Australian patients with primary open-angle glaucoma
MS Awadalla, JH Fingert, BE Roos, S Chen, R Holmes, SL Graham, ...
American journal of ophthalmology 159 (1), 124-130, 2015
922015
Angiopoietin-1 is required for Schlemm’s canal development in mice and humans
BR Thomson, T Souma, SW Tompson, T Onay, K Kizhatil, OM Siggs, ...
Journal of clinical investigation 127 (12), 4421-4436, 2017
872017
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
DE Zak, F Schmitz, ES Gold, AH Diercks, JJ Peschon, JS Valvo, ...
Proceedings of the National Academy of Sciences 108 (28), 11536-11541, 2011
762011
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
OM Siggs, B Schnabl, B Webb, B Beutler
Proceedings of the National Academy of Sciences 108 (19), 7890-7895, 2011
692011
Glaucoma spectrum and age-related prevalence of individuals with FOXC1 and PITX2 variants
E Souzeau, OM Siggs, T Zhou, A Galanopoulos, T Hodson, D Taranath, ...
European Journal of Human Genetics 25 (7), 839-847, 2017
562017
ENU-induced phenovariance in mice: inferences from 587 mutations
CN Arnold, MJ Barnes, M Berger, AL Blasius, K Brandl, B Croker, ...
BMC research notes 5, 1-14, 2012
552012
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