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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism
JM Murphy, PE Czabotar, JM Hildebrand, IS Lucet, JG Zhang, ...
Immunity 39 (3), 443-453, 2013
The molecular details of cytokine signaling via the JAK/STAT pathway
R Morris, NJ Kershaw, JJ Babon
Protein Science 27 (12), 1984-2009, 2018
Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death
JM Hildebrand, MC Tanzer, IS Lucet, SN Young, SK Spall, P Sharma, ...
Proceedings of the National Academy of Sciences 111 (42), 15072-15077, 2014
Leukemia inhibitory factor (LIF)
NA Nicola, JJ Babon
Cytokine & growth factor reviews 26 (5), 533-544, 2015
The molecular regulation of Janus kinase (JAK) activation
JJ Babon, IS Lucet, JM Murphy, NA Nicola, LN Varghese
Biochemical Journal 462 (1), 1-13, 2014
The molecular basis of JAK/STAT inhibition by SOCS1
NPD Liau, A Laktyushin, IS Lucet, JM Murphy, S Yao, E Whitlock, ...
Nature communications 9 (1), 1558, 2018
CIS is a potent checkpoint in NK cell–mediated tumor immunity
RB Delconte, TB Kolesnik, LF Dagley, J Rautela, W Shi, EM Putz, ...
Nature immunology 17 (7), 816-824, 2016
Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity
JJ Babon, NJ Kershaw, JM Murphy, LN Varghese, A Laktyushin, ...
Immunity 36 (2), 239-250, 2012
SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition
NJ Kershaw, JM Murphy, NPD Liau, LN Varghese, A Laktyushin, ...
Nature structural & molecular biology 20 (4), 469-476, 2013
A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties.
Murphy JM, Zhang Q, Young SN, Reese ML, Bailey FP, Eyers PA, Ungureanu D ...
Biochem. J 457 (2), 323-334, 2014
Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections
X Lauth, JJ Babon, JA Stannard, S Singh, V Nizet, JM Carlberg, ...
Journal of Biological Chemistry 280 (10), 9272-9282, 2005
Inhibition of IL-6 family cytokines by SOCS3
JJ Babon, LN Varghese, NA Nicola
Seminars in immunology 26 (1), 13-19, 2014
TLR7 gain-of-function genetic variation causes human lupus
GJ Brown, PF Caņete, H Wang, A Medhavy, J Bones, JA Roco, Y He, ...
Nature 605 (7909), 349-356, 2022
Suppression of cytokine signaling: the SOCS perspective
EM Linossi, JJ Babon, DJ Hilton, SE Nicholson
Cytokine & growth factor reviews 24 (3), 241-248, 2013
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability
JJ Babon, EJ McManus, S Yao, DP DeSouza, LA Mielke, NS Sprigg, ...
Molecular cell 22 (2), 205-216, 2006
Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein
C Alfano, D Sanfelice, J Babon, G Kelly, A Jacks, S Curry, MR Conte
Nature structural & molecular biology 11 (4), 323-329, 2004
The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression
JJ Babon, JK Sabo, JG Zhang, NA Nicola, RS Norton
Journal of molecular biology 387 (1), 162-174, 2009
Structure and function of the SPRY/B30. 2 domain proteins involved in innate immunity
AA D'Cruz, JJ Babon, RS Norton, NA Nicola, SE Nicholson
Protein Science 22 (1), 1-10, 2013
The biology and mechanism of action of suppressor of cytokine signaling 3
JJ Babon, NA Nicola
Growth factors 30 (4), 207-219, 2012
Stabilization of neurotoxic soluble β-sheet-rich conformations of the Alzheimer's disease amyloid-β peptide
DJ Tew, SP Bottomley, DP Smith, GD Ciccotosto, J Babon, MG Hinds, ...
Biophysical journal 94 (7), 2752-2766, 2008
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