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Zeyu Chen
Zeyu Chen
Dana Farber Cancer Institute/Harvard Medical School/Broad Institute
Verified email at broadinstitute.org
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Cited by
Year
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ...
Science 369 (6508), eabc8511, 2020
14412020
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
KE Pauken, MA Sammons, PM Odorizzi, S Manne, J Godec, O Khan, ...
Science 354 (6316), 1160-1165, 2016
10992016
T cell responses in patients with COVID-19
Z Chen, E John Wherry
Nature Reviews Immunology 20 (9), 529-536, 2020
8372020
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, Z Chen, ...
Immunity 52 (5), 825-841. e8, 2020
5702020
Tumor cell-intrinsic factors underlie heterogeneity of immune cell infiltration and response to immunotherapy
J Li, KT Byrne, F Yan, T Yamazoe, Z Chen, T Baslan, LP Richman, JH Lin, ...
Immunity 49 (1), 178-193. e7, 2018
5602018
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
Z Chen, Z Ji, SF Ngiow, S Manne, Z Cai, AC Huang, J Johnson, ...
Immunity 51 (5), 840-855. e5, 2019
4842019
CRISPR/Cas9-mediated CCR5 ablation in human hematopoietic stem/progenitor cells confers HIV-1 resistance in vivo
L Xu, H Yang, Y Gao, Z Chen, L Xie, Y Liu, Y Liu, X Wang, H Li, W Lai, ...
Molecular Therapy 25 (8), 1782-1789, 2017
2482017
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
LA Vella, JR Giles, AE Baxter, DA Oldridge, C Diorio, L Kuri-Cervantes, ...
Science immunology 6 (57), eabf7570, 2021
1902021
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation
MS Abdel-Hakeem, S Manne, JC Beltra, E Stelekati, Z Chen, K Nzingha, ...
Nature immunology 22 (8), 1008-1019, 2021
1372021
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Z Chen, E Arai, O Khan, Z Zhang, SF Ngiow, Y He, H Huang, S Manne, ...
Cell 184 (5), 1262-1280. e22, 2021
1132021
Deep immune profiling of COVID-19 patients reveals patient heterogeneity and distinct immunotypes with implications for therapeutic interventions
D Mathew, JR Giles, AE Baxter, AR Greenplate, JE Wu, C Alanio, ...
BioRxiv, 2020
1112020
UPenn COVID Processing Unit
D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ...
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with …, 2020
962020
Long-Term Persistence of Exhausted CD8 T Cells in Chronic Infection Is Regulated by MicroRNA-155
E Stelekati, Z Chen, S Manne, M Kurachi, MA Ali, K Lewy, Z Cai, ...
Cell reports 23 (7), 2142-2156, 2018
892018
BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells
C Yao, G Lou, HW Sun, Z Zhu, Y Sun, Z Chen, D Chauss, EA Moseman, ...
Nature immunology 22 (3), 370-380, 2021
862021
miR-150 regulates memory CD8 T cell differentiation via c-Myb
Z Chen, E Stelekati, M Kurachi, S Yu, Z Cai, S Manne, O Khan, X Yang, ...
Cell reports 20 (11), 2584-2597, 2017
782017
Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
LM McLane, SF Ngiow, Z Chen, J Attanasio, S Manne, G Ruthel, JE Wu, ...
Cell reports 35 (6), 2021
722021
The identity of human tissue-emigrant CD8+ T cells
M Buggert, LA Vella, S Nguyen, VH Wu, Z Chen, T Sekine, A Perez-Potti, ...
Cell 183 (7), 1946-1961. e15, 2020
662020
Inhibitory signaling sustains a distinct early memory CD8+ T cell precursor that is resistant to DNA damage
JB Johnnidis, Y Muroyama, SF Ngiow, Z Chen, S Manne, Z Cai, S Song, ...
Science immunology 6 (55), eabe3702, 2021
632021
Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function
M Kurachi, J Kurachi, Z Chen, J Johnson, O Khan, B Bengsch, E Stelekati, ...
Nature protocols 12 (9), 1980-1998, 2017
602017
Systematically labeling developmental stage-specific genes for the study of pancreatic β-cell differentiation from human embryonic stem cells
H Liu, H Yang, D Zhu, X Sui, J Li, Z Liang, L Xu, Z Chen, A Yao, L Zhang, ...
Cell research 24 (10), 1181-1200, 2014
602014
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