Jean-Yves Winum
Jean-Yves Winum
Professor of Chemistry - University of Montpellier
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Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors
Y Lou, PC McDonald, A Oloumi, S Chia, C Ostlund, A Ahmadi, A Kyle, ...
Cancer research 71 (9), 3364-3376, 2011
Recent developments in targeting carbonic anhydrase IX for cancer therapeutics
PC McDonald, JY Winum, CT Supuran, S Dedhar
Oncotarget 3 (1), 84, 2012
Carbonic anhydrase IX: a new druggable target for the design of antitumor agents
JY Winum, M Rami, A Scozzafava, JL Montero, C Supuran
Medicinal research reviews 28 (3), 445-463, 2008
Glycosyl coumarin carbonic anhydrase IX and XII inhibitors strongly attenuate the growth of primary breast tumors
N Touisni, A Maresca, PC McDonald, Y Lou, A Scozzafava, S Dedhar, ...
Journal of medicinal chemistry 54 (24), 8271-8277, 2011
Sulfamates and their therapeutic potential
JY Winum, A Scozzafava, JL Montero, CT Supuran
Medicinal research reviews 25 (2), 186-228, 2005
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic …
A Cecchi, A Hulikova, J Pastorek, S Pastoreková, A Scozzafava, ...
Journal of medicinal chemistry 48 (15), 4834-4841, 2005
Therapeutic potential of sulfamides as enzyme inhibitors
JY Winum, A Scozzafava, JL Montero, CT Supuran
Medicinal research reviews 26 (6), 767-792, 2006
Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1, 3, 5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II …
V Garaj, L Puccetti, G Fasolis, JY Winum, JL Montero, A Scozzafava, ...
Bioorganic & medicinal chemistry letters 15 (12), 3102-3108, 2005
Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts
RG Gieling, M Babur, L Mamnani, N Burrows, BA Telfer, F Carta, ...
Journal of medicinal chemistry 55 (11), 5591-5600, 2012
Carbonic anhydrase inhibitors. Inhibition of cytosolic isozymes I and II and transmembrane, tumor-associated isozyme IX with sulfamates including EMATE also acting as steroid …
JY Winum, D Vullo, A Casini, JL Montero, A Scozzafava, CT Supuran
Journal of Medicinal Chemistry 46 (11), 2197-2204, 2003
Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the …
JY Winum, C Temperini, K El Cheikh, A Innocenti, D Vullo, S Ciattini, ...
Journal of Medicinal Chemistry 49 (24), 7024-7031, 2006
Carbonic anhydrase IX inhibitors in cancer therapy: an update
CT Supuran, JY Winum
Future medicinal chemistry 7 (11), 1407-1414, 2015
Carbonic anhydrase inhibitors: X-ray crystallographic structure of the adduct of human isozyme II with EMATE, a dual inhibitor of carbonic anhydrases and steroid sulfatase
F Abbate, JY Winum, BVL Potter, A Casini, JL Montero, A Scozzafava, ...
Bioorganic & medicinal chemistry letters 14 (1), 231-234, 2004
Drug design of zinc-enzyme inhibitors: functional, structural, and disease applications
B Wang
John Wiley & Sons, 2009
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1, 2, 4-triazine …
V Garaj, L Puccetti, G Fasolis, JY Winum, JL Montero, A Scozzafava, ...
Bioorganic & Medicinal Chemistry Letters 14 (21), 5427-5433, 2004
Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
A Angeli, F Carta, A Nocentini, JY Winum, R Zalubovskis, A Akdemir, ...
Metabolites 10 (10), 412, 2020
Therapeutic applications of glycosidic carbonic anhydrase inhibitors
JY Winum, SA Poulsen, CT Supuran
Medicinal research reviews 29 (3), 419-435, 2009
Cloning, Characterization, and Inhibition Studies of a β-Carbonic Anhydrase from Brucella suis
P Joseph, F Turtaut, S Ouahrani-Bettache, JL Montero, I Nishimori, ...
Journal of medicinal chemistry 53 (5), 2277-2285, 2010
Carbonic anhydrase inhibitors: hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX
G De Simone, RM Vitale, A Di Fiore, C Pedone, A Scozzafava, JL Montero, ...
Journal of medicinal chemistry 49 (18), 5544-5551, 2006
Carbonic anhydrase inhibitor coated gold nanoparticles selectively inhibit the tumor-associated isoform IX over the cytosolic isozymes I and II
M Stiti, A Cecchi, M Rami, M Abdaoui, V Barragan-Montero, A Scozzafava, ...
Journal of the American Chemical Society 130 (48), 16130-16131, 2008
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