Francesco Iorio
Francesco Iorio
Wellcome Sanger Institute
Verified email at sanger.ac.uk
Title
Cited by
Cited by
Year
Systematic identification of genomic markers of drug sensitivity in cancer cells
MJ Garnett, EJ Edelman, SJ Heidorn, CD Greenman, A Dastur, KW Lau, ...
Nature 483 (7391), 570-575, 2012
21182012
Drug repurposing: progress, challenges and recommendations
S Pushpakom, F Iorio, PA Eyers, KJ Escott, S Hopper, A Wells, A Doig, ...
Nature reviews Drug discovery 18 (1), 41-58, 2019
14072019
Prospective derivation of a living organoid biobank of colorectal cancer patients
M van de Wetering, HE Francies, JM Francis, G Bounova, F Iorio, A Pronk, ...
Cell 161 (4), 933-945, 2015
13362015
A landscape of pharmacogenomic interactions in cancer
F Iorio, TA Knijnenburg, DJ Vis, GR Bignell, MP Menden, M Schubert, ...
Cell 166 (3), 740-754, 2016
10482016
Heterogeneity of genomic evolution and mutational profiles in multiple myeloma
N Bolli, H Avet-Loiseau, DC Wedge, P Van Loo, LB Alexandrov, ...
Nature communications 5 (1), 1-13, 2014
7512014
Discovery of drug mode of action and drug repositioning from transcriptional responses
F Iorio, R Bosotti, E Scacheri, V Belcastro, P Mithbaokar, R Ferriero, ...
Proceedings of the National Academy of Sciences 107 (33), 14621-14626, 2010
7342010
Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens
FM Behan, F Iorio, G Picco, E Gonçalves, CM Beaver, G Migliardi, ...
Nature 568 (7753), 511-516, 2019
4672019
A yeast synthetic network for in vivo assessment of reverse-engineering and modeling approaches
I Cantone, L Marucci, F Iorio, MA Ricci, V Belcastro, M Bansal, S Santini, ...
Cell 137 (1), 172-181, 2009
3952009
Machine learning prediction of cancer cell sensitivity to drugs based on genomic and chemical properties
MP Menden, F Iorio, M Garnett, U McDermott, CH Benes, PJ Ballester, ...
PLoS one 8 (4), e61318, 2013
3792013
A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ...
Cell reports 17 (4), 1193-1205, 2016
3752016
Transcriptional data: a new gateway to drug repositioning?
F Iorio, T Rittman, H Ge, M Menden, J Saez-Rodriguez
Drug discovery today 18 (7-8), 350-357, 2013
2052013
Pharmacogenomic agreement between two cancer cell line data sets
Cancer Cell Line Encyclopedia Consortium, ...
Nature 528 (7580), 84-87, 2015
2002015
Characterizing mutational signatures in human cancer cell lines reveals episodic APOBEC mutagenesis
M Petljak, LB Alexandrov, JS Brammeld, S Price, DC Wedge, ...
Cell 176 (6), 1282-1294. e20, 2019
1762019
BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma model
D Perna, FA Karreth, AG Rust, PA Perez-Mancera, M Rashid, F Iorio, ...
Proceedings of the National Academy of Sciences 112 (6), E536-E545, 2015
1212015
Transcriptional gene network inference from a massive dataset elucidates transcriptome organization and gene function
V Belcastro, V Siciliano, F Gregoretti, P Mithbaokar, G Dharmalingam, ...
Nucleic acids research 39 (20), 8677-8688, 2011
1112011
Identifying network of drug mode of action by gene expression profiling
F Iorio, R Tagliaferri, D Bernardo
Journal of Computational Biology 16 (2), 241-251, 2009
1052009
Transcription factor activities enhance markers of drug sensitivity in cancer
L Garcia-Alonso, F Iorio, A Matchan, N Fonseca, P Jaaks, G Peat, ...
Cancer research 78 (3), 769-780, 2018
942018
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts
A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ...
Leukemia 31 (3), 720-727, 2017
942017
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets
JM Dempster, C Pacini, S Pantel, FM Behan, T Green, J Krill-Burger, ...
Nature communications 10 (1), 1-14, 2019
702019
CellMinerCDB for integrative cross-database genomics and pharmacogenomics analyses of cancer cell lines
VN Rajapakse, A Luna, M Yamade, L Loman, S Varma, M Sunshine, ...
Iscience 10, 247-264, 2018
632018
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