| Tumorigenicity of the optical enantiomers of the diastereomeric benzo [a] pyrene 7, 8-diol-9, 10-epoxides in newborn mice: exceptional activity of (+)-7beta, 8alpha-dihydroxy … MK Buening, PG Wislocki, W Levin, H Yagi, DR Thakker, H Akagi, ... Proceedings of the National Academy of Sciences 75 (11), 5358-5361, 1978 | 584 | 1978 |
| Polycyclic aromatic hydrocarbons: metabolic activation to ultimate carcinogens DR Thakker, H Yagi, W Levin, AW Wood, AH Conney, DM Jerina Bioactivation of foreign compounds, 177-242, 1985 | 361 | 1985 |
| Metabolism of benzo [a] pyrene: conversion of (+/-)-trans-7, 8-dihydroxy-7, 8-dihydrobenzo [a] pyrene to highly mutagenic 7, 8-diol-9, 10-epoxides. DR Thakker, H Yagi, AY Lu, W Levin, AH Conney Proceedings of the National Academy of Sciences 73 (10), 3381-3385, 1976 | 349 | 1976 |
| Metabolism of benzo [a] pyrene VI. Stereoselective metabolism of benzo [a] pyrene and benzo [a] pyrene 7, 8-dihydrodiol to diol epoxides DR Thakker, H Yagi, H Akagi, M Koreeda, AYH Lu, W Levin, AW Wood, ... Chemico-biological interactions 16 (3), 281-300, 1977 | 336 | 1977 |
| Enhancing paracellular permeability by modulating epithelial tight junctions PD Ward, TK Tippin, DR Thakker Pharmaceutical science & technology today 3 (10), 346-358, 2000 | 269 | 2000 |
| Applications of the Caco-2 model in the design and development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium LSL Gan, DR Thakker Advanced Drug Delivery Reviews 23 (1-3), 77-98, 1997 | 246 | 1997 |
| Differences in mutagenicity of the optical enantiomers of the diastereomeric benzo [a] pyrene 7, 8-diol-9, 10-epoxides AW Wood, RL Chang, W Levin, H Yagi, DR Thakker, DM Jerina, ... Biochemical and Biophysical Research Communications 77 (4), 1389-1396, 1977 | 238 | 1977 |
| Synthesis and reactions of the highly mutagenic 7, 8-diol 9, 10-epoxides of the carcinogen benzo [a] pyrene H Yagi, DR Thakker, O Hernandez, M Koreeda, DM Jerina Journal of the American Chemical Society 99 (5), 1604-1611, 1977 | 222 | 1977 |
| Evidence for a polarized efflux system in Caco-2 cells capable of modulating cyclosporine A transport PF Augustijns, TP Bradshaw, LSL Gan, RW Hendren, DR Thakker Biochemical and biophysical research communications 197 (2), 360-365, 1993 | 219 | 1993 |
| CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells. LS Gan, MA Moseley, B Khosla, PF Augustijns, TP Bradshaw, ... Drug Metabolism and Disposition 24 (3), 344-349, 1996 | 215 | 1996 |
| Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium MD Troutman, DR Thakker Pharmaceutical research 20, 1210-1224, 2003 | 202 | 2003 |
| Metabolism of chrysene and phenanthrene to bay-region diol epoxides by rat liver enzymes M Nordqvist, DR Thakker, KP Vyas, H Yagi, W Levin, DE Ryan, ... Molecular pharmacology 19 (1), 168-178, 1981 | 191* | 1981 |
| Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 … MD Troutman, DR Thakker Pharmaceutical research 20, 1200-1209, 2003 | 182 | 2003 |
| Oxidative metabolism of polycyclic aromatic hydrocarbons to ultimate carcinogens W Levin, A Wood, R Chang, D Ryan, P Thomas, H Yagi, D Thakker, ... Drug metabolism reviews 13 (4), 555-580, 1982 | 180 | 1982 |
| Mechanisms underlying saturable intestinal absorption of metformin WR Proctor, DL Bourdet, DR Thakker Drug Metabolism and Disposition 36 (8), 1650-1658, 2008 | 167 | 2008 |
| Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells MD Troutman, DR Thakker Pharmaceutical research 20, 1192-1199, 2003 | 161 | 2003 |
| Prodrugs of anticancer agents AK Sinhababu, DR Thakker Advanced drug delivery reviews 19 (2), 241-273, 1996 | 158 | 1996 |
| In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3 SB Yanni, PP Annaert, P Augustijns, JG Ibrahim, DK Benjamin, ... Drug Metabolism and Disposition 38 (1), 25-31, 2010 | 143 | 2010 |
| Tumorigenicity of Optical Isomers of the Diastereomeric Bay-Region 3,4-Diol-1,2-epoxides of Benzo(c)phenanthrene in Murine Tumor Models W Levin, RL Chang, AW Wood, DR Thakker, H Yagi, DM Jerina, ... Cancer research 46 (5), 2257-2261, 1986 | 139 | 1986 |
| Evidence That Benzo(a)anthracene 3,4-Diol-1,2-Epoxide Is an Ultimate Carcinogen on Mouse Skin W Levin, DR Thakker, AW Wood, RL Chang, RE Lehr, DM Jerina, ... Cancer research 38 (6), 1705-1710, 1978 | 138 | 1978 |
