| Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins R Halfmann, S Alberti, R Krishnan, N Lyle, CW O'Donnell, OD King, ... Molecular cell 43 (1), 72-84, 2011 | 200 | 2011 |
| Describing sequence–ensemble relationships for intrinsically disordered proteins AH Mao, N Lyle, RV Pappu Biochemical Journal 449 (2), 307-318, 2013 | 141 | 2013 |
| Quantitative assessments of the distinct contributions of polypeptide backbone amides versus side chain groups to chain expansion via chemical denaturation AS Holehouse, K Garai, N Lyle, A Vitalis, RV Pappu Journal of the American Chemical Society 137 (8), 2984-2995, 2015 | 110 | 2015 |
| Thermodynamics of β-sheet formation in polyglutamine A Vitalis, N Lyle, RV Pappu Biophysical Journal 97 (1), 303-311, 2009 | 103 | 2009 |
| Experiments and simulations show how long-range contacts can form in expanded unfolded proteins with negligible secondary structure W Meng, N Lyle, B Luan, DP Raleigh, RV Pappu Proceedings of the National Academy of Sciences 110 (6), 2123-2128, 2013 | 88 | 2013 |
| A quantitative measure for protein conformational heterogeneity N Lyle, RK Das, RV Pappu The Journal of chemical physics 139 (12), 2013 | 70 | 2013 |
| The denatured state ensemble contains significant local and long-range structure under native conditions: analysis of the N-terminal domain of ribosomal protein L9 W Meng, B Luan, N Lyle, RV Pappu, DP Raleigh Biochemistry 52 (15), 2662-2671, 2013 | 39 | 2013 |
| Hamiltonian switch metropolis Monte Carlo simulations for improved conformational sampling of intrinsically disordered regions tethered to ordered domains of proteins A Mittal, N Lyle, TS Harmon, RV Pappu Journal of chemical theory and computation 10 (8), 3550-3562, 2014 | 37 | 2014 |
| Subcellular localization and Ser-137 phosphorylation regulate tumor-suppressive activity of profilin-1 MI Diamond, S Cai, A Boudreau, CJ Carey, N Lyle, RV Pappu, ... Journal of Biological Chemistry 290 (14), 9075-9086, 2015 | 28 | 2015 |
| Denatured state ensembles with the same radii of gyration can form significantly different long-range contacts B Luan, N Lyle, RV Pappu, DP Raleigh Biochemistry 53 (1), 39-47, 2014 | 21 | 2014 |
| Alterations to the Conformational Ensemble and Intermolecular Associations of Polyglutamine Due to Charged Side Chains at the N-and C-Termini NJ Lyle, SL Crick, RV Pappu Biophysical Journal 100 (3), 63a, 2011 | 1 | 2011 |
| Inhibition of Nuclear Pfn1 by Ser-137 Phosphorylation MI Diamond, S Cai, A Boudreau, CJ Carey Jr, N Lyle, RV Pappu, ... | | 2015 |
| Parsing the Contributions of Polypeptide Backbones and Sidechains to Denaturation in Concentrated Aqueous Solutions of Urea and Guanidinium Chloride AS Holehouse, N Lyle, A Vitalis, D Thirumalai, RV Pappu Biophysical Journal 106 (2), 484a, 2014 | | 2014 |
| Coarse Grain Simulations Providing a Unifying Framework for Explaining Polyglutamine Aggregation Mechanism S Khan, N Lyle, RV Pappu Biophysical Journal 104 (2), 388a-389a, 2013 | | 2013 |
| Modulation of Polyglutamine Conformations and Associations by C-Terminal Proline Rich Regions from Exon 1 of Huntingtin K Ruff, N Lyle, RV Pappu Biophysical Journal 104 (2), 233a, 2013 | | 2013 |
| Quantifying Disorder using Simulated Ensembles for Different Classes of Polypeptides NJ Lyle, RV Pappu Biophysical Journal 104 (2), 53a, 2013 | | 2013 |
| Quantification of conformational heterogeneity and its role in protein aggregation and unfolding NJ Lyle Washington University in St. Louis, 2013 | | 2013 |
| Simulations of Denatured Protein Ensembles Reproduce and Rationalize Experimental Observations of Persistent Contacts Between Residues Distal in Protein Sequence NJ Lyle, W Meng, DP Raleigh, RV Pappu Biophysical Journal 102 (3), 630a, 2012 | | 2012 |
| Implications Of Cis Interactions Between Expanded Polyglutamine and the Proline Rich C-Terminal Domain of Huntingtin Exon 1 For the Loss-Versus Gain-Of-Function Models of … K Ruff, N Lyle, RV Pappu Biophysical Journal 102 (3), 256a, 2012 | | 2012 |
| Parameter Refinement, Optimization, and Extension of the Absinth Implicit Solvation Model NJ Lyle, RV Pappu Biophysical Journal 98 (3), 574a, 2010 | | 2010 |
