Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA,IDH1,EGFR, and NF1 RGW Verhaak, KA Hoadley, E Purdom, V Wang, Y Qi, MD Wilkerson, ... Cancer cell 17 (1), 98-110, 2010 | 8078 | 2010 |
Comprehensive genomic characterization defines human glioblastoma genes and core pathways R McLendon, A Friedman, D Bigner, EG Van Meir, DJ Brat, ... Nature 455 (7216), 1061-1068, 2008 | 7444 | 2008 |
The landscape of somatic copy-number alteration across human cancers R Beroukhim, CH Mermel, D Porter, G Wei, S Raychaudhuri, J Donovan, ... Nature 463 (7283), 899-905, 2010 | 4381 | 2010 |
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 DA Barbie, P Tamayo, JS Boehm, SY Kim, SE Moody, IF Dunn, ... Nature 462 (7269), 108-112, 2009 | 3283 | 2009 |
Somatic mutations affect key pathways in lung adenocarcinoma L Ding, G Getz, DA Wheeler, ER Mardis, MD McLellan, K Cibulskis, ... Nature 455 (7216), 1069-1075, 2008 | 3139 | 2008 |
Next-generation characterization of the Cancer Cell Line Encyclopedia M Ghandi, FW Huang, J Jané-Valbuena, GV Kryukov, CC Lo, ... Nature 569 (7757), 503, 2019 | 2656 | 2019 |
Defining a cancer dependency map A Tsherniak, F Vazquez, PG Montgomery, BA Weir, G Kryukov, ... Cell 170 (3), 564-576. e16, 2017 | 2264 | 2017 |
Absolute quantification of somatic DNA alterations in human cancer SL Carter, K Cibulskis, E Helman, A McKenna, H Shen, T Zack, PW Laird, ... Nature biotechnology 30 (5), 413, 2012 | 2046 | 2012 |
Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells RM Meyers, JG Bryan, JM McFarland, BA Weir, AE Sizemore, H Xu, ... Nature genetics 49 (12), 1779, 2017 | 1660 | 2017 |
Characterizing the cancer genome in lung adenocarcinoma BA Weir, MS Woo, G Getz, S Perner, L Ding, R Beroukhim, WM Lin, ... Nature 450 (7171), 893-898, 2007 | 1291 | 2007 |
Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study K Shedden, JMG Taylor, SA Enkemann, MS Tsao, TJ Yeatman, ... Nature medicine 14 (8), 822-827, 2008 | 1139 | 2008 |
SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas AJ Bass, H Watanabe, CH Mermel, S Yu, S Perner, RG Verhaak, SY Kim, ... Nature genetics 41 (11), 1238, 2009 | 1083 | 2009 |
β-Catenin-driven cancers require a YAP1 transcriptional complex for survival and tumorigenesis J Rosenbluh, D Nijhawan, AG Cox, X Li, JT Neal, EJ Schafer, TI Zack, ... Cell 151 (7), 1457-1473, 2012 | 839 | 2012 |
Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy J Barretina, BS Taylor, S Banerji, AH Ramos, M Lagos-Quintana, ... Nature genetics 42 (8), 715, 2010 | 805 | 2010 |
Genomic copy number dictates a gene-independent cell response to CRISPR/Cas9 targeting AJ Aguirre, RM Meyers, BA Weir, F Vazquez, CZ Zhang, U Ben-David, ... Cancer discovery 6 (8), 914-929, 2016 | 670 | 2016 |
PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR ML Sos, M Koker, BA Weir, S Heynck, R Rabinovsky, T Zander, ... Cancer research 69 (8), 3256-3261, 2009 | 660 | 2009 |
Highly parallel identification of essential genes in cancer cells B Luo, HW Cheung, A Subramanian, T Sharifnia, M Okamoto, X Yang, ... Proceedings of the National Academy of Sciences 105 (51), 20380-20385, 2008 | 648 | 2008 |
Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway CA Lovejoy, W Li, S Reisenweber, S Thongthip, J Bruno, T De Lange, ... PLoS genetics 8 (7), e1002772, 2012 | 627 | 2012 |
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer HW Cheung, GS Cowley, BA Weir, JS Boehm, S Rusin, JA Scott, A East, ... Proceedings of the National Academy of Sciences 108 (30), 12372-12377, 2011 | 516 | 2011 |
Prognostic and predictive gene signature for adjuvant chemotherapy in resected non–small-cell lung cancer CQ Zhu, K Ding, D Strumpf, BA Weir, M Meyerson, N Pennell, RK Thomas, ... Journal of Clinical Oncology 28 (29), 4417-4424, 2010 | 509 | 2010 |