Johnny Habchi
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Introducing protein intrinsic disorder
J Habchi, P Tompa, S Longhi, VN Uversky
Chemical reviews 114 (13), 6561-6588, 2014
Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017
An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
Structural disorder in viral proteins
B Xue, D Blocquel, J Habchi, AV Uversky, L Kurgan, VN Uversky, ...
Chemical reviews 114 (13), 6880-6911, 2014
Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, ...
Nature chemistry 10 (6), 673-683, 2018
Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation
J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
Annual review of physical chemistry 69, 273-98, 2018
The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments
D Granata, F Baftizadeh, J Habchi, C Galvagnion, A De Simone, ...
Scientific reports 5 (1), 1-15, 2015
Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Nature communications 10 (1), 1-13, 2019
Structural disorder within Henipavirus nucleoprotein and phosphoprotein: from predictions to experimental assessment
J Habchi, L Mamelli, H Darbon, S Longhi
PLoS One 5 (7), e11684, 2010
AFM-based single molecule techniques: unraveling the amyloid pathogenic species
FS Ruggeri, J Habchi, A Cerreta, G Dietler
Current pharmaceutical design 22 (26), 3950-3970, 2016
Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus
G Communie, J Habchi, F Yabukarski, D Blocquel, R Schneider, ...
PLoS pathogens 9 (9), e1003631, 2013
Structural disorder within paramyxovirus nucleoproteins and phosphoproteins
J Habchi, S Longhi
Molecular Biosystems 8 (1), 69-81, 2012
Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus
J Habchi, S Blangy, L Mamelli, MR Jensen, M Blackledge, H Darbon, ...
Journal of Biological Chemistry 286 (15), 13583-13602, 2011
Molecular basis for structural heterogeneity of an intrinsically disordered protein bound to a partner by combined ESI-IM-MS and modeling
A D’Urzo, A Konijnenberg, G Rossetti, J Habchi, J Li, P Carloni, F Sobott, ...
Journal of The American Society for Mass Spectrometry 26 (3), 472-481, 2014
Compaction and binding properties of the intrinsically disordered C-terminal domain of Henipavirus nucleoprotein as unveiled by deletion studies
D Blocquel, J Habchi, A Gruet, S Blangy, S Longhi
Molecular bioSystems 8 (1), 392-410, 2012
Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ...
Journal of neuroscience methods 306, 57-67, 2018
SAR by kinetics for drug discovery in protein misfolding diseases
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, ...
Proceedings of the National Academy of Sciences 115 (41), 10245-10250, 2018
Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus
Y Shu, J Habchi, S Costanzo, A Padilla, J Brunel, D Gerlier, M Oglesbee, ...
Journal of Biological Chemistry 287 (15), 11951-11967, 2012
Assessing induced folding within the intrinsically disordered C-terminal domain of the Henipavirus nucleoproteins by site-directed spin labeling EPR spectroscopy
M Martinho, J Habchi, Z El Habre, L Nesme, B Guigliarelli, V Belle, ...
Journal of Biomolecular Structure and Dynamics 31 (5), 453-471, 2013
A fragment-based method of creating small-molecule libraries to target the aggregation of intrinsically disordered proteins
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
ACS combinatorial science 18 (3), 144-153, 2016
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Articles 1–20