|Introducing protein intrinsic disorder|
J Habchi, P Tompa, S Longhi, VN Uversky
Chemical reviews 114 (13), 6561-6588, 2014
|Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease|
J Habchi, S Chia, R Limbocker, B Mannini, M Ahn, M Perni, O Hansson, ...
Proceedings of the National Academy of Sciences 114 (2), E200-E208, 2017
|An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer’s disease|
J Habchi, P Arosio, M Perni, AR Costa, M Yagi-Utsumi, P Joshi, S Chia, ...
Science advances 2 (2), e1501244, 2016
|Structural disorder in viral proteins|
B Xue, D Blocquel, J Habchi, AV Uversky, L Kurgan, VN Uversky, ...
Chemical reviews 114 (13), 6880-6911, 2014
|Cholesterol catalyses Aβ42 aggregation through a heterogeneous nucleation pathway in the presence of lipid membranes|
J Habchi, S Chia, C Galvagnion, TCT Michaels, MMJ Bellaiche, ...
Nature chemistry 10 (6), 673-683, 2018
|Chemical kinetics for bridging molecular mechanisms and macroscopic measurements of amyloid fibril formation|
J Habchi, S Chia, G Meisl, M Vendruscolo, CM Dobson, TPJ Knowles
Annual review of physical chemistry 69, 273-98, 2018
|The inverted free energy landscape of an intrinsically disordered peptide by simulations and experiments|
D Granata, F Baftizadeh, J Habchi, C Galvagnion, A De Simone, ...
Scientific reports 5 (1), 1-15, 2015
|Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes|
R Limbocker, S Chia, FS Ruggeri, M Perni, R Cascella, GT Heller, G Meisl, ...
Nature communications 10 (1), 1-13, 2019
|Structural disorder within Henipavirus nucleoprotein and phosphoprotein: from predictions to experimental assessment|
J Habchi, L Mamelli, H Darbon, S Longhi
PLoS One 5 (7), e11684, 2010
|AFM-based single molecule techniques: unraveling the amyloid pathogenic species|
FS Ruggeri, J Habchi, A Cerreta, G Dietler
Current pharmaceutical design 22 (26), 3950-3970, 2016
|Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus|
G Communie, J Habchi, F Yabukarski, D Blocquel, R Schneider, ...
PLoS pathogens 9 (9), e1003631, 2013
|Structural disorder within paramyxovirus nucleoproteins and phosphoproteins|
J Habchi, S Longhi
Molecular Biosystems 8 (1), 69-81, 2012
|Characterization of the interactions between the nucleoprotein and the phosphoprotein of Henipavirus|
J Habchi, S Blangy, L Mamelli, MR Jensen, M Blackledge, H Darbon, ...
Journal of Biological Chemistry 286 (15), 13583-13602, 2011
|Molecular basis for structural heterogeneity of an intrinsically disordered protein bound to a partner by combined ESI-IM-MS and modeling|
A D’Urzo, A Konijnenberg, G Rossetti, J Habchi, J Li, P Carloni, F Sobott, ...
Journal of The American Society for Mass Spectrometry 26 (3), 472-481, 2014
|Compaction and binding properties of the intrinsically disordered C-terminal domain of Henipavirus nucleoprotein as unveiled by deletion studies|
D Blocquel, J Habchi, A Gruet, S Blangy, S Longhi
Molecular bioSystems 8 (1), 392-410, 2012
|Massively parallel C. elegans tracking provides multi-dimensional fingerprints for phenotypic discovery|
M Perni, PK Challa, JB Kirkegaard, R Limbocker, M Koopman, ...
Journal of neuroscience methods 306, 57-67, 2018
|SAR by kinetics for drug discovery in protein misfolding diseases|
S Chia, J Habchi, TCT Michaels, SIA Cohen, S Linse, CM Dobson, ...
Proceedings of the National Academy of Sciences 115 (41), 10245-10250, 2018
|Plasticity in structural and functional interactions between the phosphoprotein and nucleoprotein of measles virus|
Y Shu, J Habchi, S Costanzo, A Padilla, J Brunel, D Gerlier, M Oglesbee, ...
Journal of Biological Chemistry 287 (15), 11951-11967, 2012
|Assessing induced folding within the intrinsically disordered C-terminal domain of the Henipavirus nucleoproteins by site-directed spin labeling EPR spectroscopy|
M Martinho, J Habchi, Z El Habre, L Nesme, B Guigliarelli, V Belle, ...
Journal of Biomolecular Structure and Dynamics 31 (5), 453-471, 2013
|A fragment-based method of creating small-molecule libraries to target the aggregation of intrinsically disordered proteins|
P Joshi, S Chia, J Habchi, TPJ Knowles, CM Dobson, M Vendruscolo
ACS combinatorial science 18 (3), 144-153, 2016