Hazem A. Ghabbour
Hazem A. Ghabbour
Assistant Professor Medicinal Chemistry Department, college of Pharmacy, Mansoura University.
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Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene) thiazolidin-2-ylidene) amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and …
WM Eldehna, MF Abo-Ashour, A Nocentini, P Gratteri, IH Eissa, M Fares, ...
European journal of medicinal chemistry 139, 250-262, 2017
Sickle cell disease in S audi A rabia: the phenotype in adults with the A rab‐I ndian haplotype is not benign
A Alsultan, MK Alabdulaali, PJ Griffin, AM AlSuliman, HA Ghabbour, ...
British journal of haematology 164 (4), 597-604, 2014
Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1 …
WM Eldehna, SM Abou-Seri, AM El Kerdawy, RR Ayyad, AM Hamdy, ...
European Journal of Medicinal Chemistry 113, 50-62, 2016
Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII
WM Eldehna, M Fares, M Ceruso, HA Ghabbour, SM Abou-Seri, ...
European journal of medicinal chemistry 110, 259-266, 2016
Fluorescence spectroscopic and molecular docking studies of the binding interaction between the new anaplastic lymphoma kinase inhibitor crizotinib and bovine serum albumin
AS Abdelhameed, AM Alanazi, AH Bakheit, HW Darwish, HA Ghabbour, ...
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 171, 174-182, 2017
Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA …
WM Eldehna, H Almahli, GH Al-Ansary, HA Ghabbour, MH Aly, OE Ismael, ...
Journal of Enzyme Inhibition and Medicinal Chemistry 32 (1), 600-613, 2017
Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation
WM Eldehna, MF Abo-Ashour, HS Ibrahim, GH Al-Ansary, HA Ghabbour, ...
Journal of enzyme inhibition and medicinal chemistry 33 (1), 686-700, 2018
Synthesis and anticancer activity of new quinazoline derivatives
HA Abuelizz, M Marzouk, H Ghabbour, R Al-Salahi
Saudi Pharmaceutical Journal 25 (7), 1047-1054, 2017
Synthesis and structure investigation of novel pyrimidine-2, 4, 6-trione derivatives of highly potential biological activity as anti-diabetic agent
A Barakat, SM Soliman, AM Al-Majid, G Lotfy, HA Ghabbour, HK Fun, ...
Journal of Molecular Structure 1098, 365-376, 2015
Development of novel synthesized phthalazinone-based PARP-1 inhibitors with apoptosis inducing mechanism in lung cancer
H Almahli, E Hadchity, MY Jaballah, R Daher, HA Ghabbour, MM Kabil, ...
Bioorganic Chemistry 77, 443-456, 2018
Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and …
WM Eldehna, GH Al-Ansary, S Bua, A Nocentini, P Gratteri, A Altoukhy, ...
European Journal of Medicinal Chemistry 127, 521-530, 2017
One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells
WM Eldehna, DH El-Naggar, AR Hamed, HS Ibrahim, HA Ghabbour, ...
Journal of enzyme inhibition and medicinal chemistry 33 (1), 309-318, 2018
Substituted spirooxindole derivatives as potent anticancer agents through inhibition of phosphodiesterase 1
A Barakat, MS Islam, HM Ghawas, AM Al-Majid, FF El-Senduny, ...
RSC advances 8 (26), 14335-14346, 2018
Design and synthesis of new substituted spirooxindoles as potential inhibitors of the MDM2–p53 interaction
A Barakat, MS Islam, HM Ghawas, AM Al-Majid, FF El-Senduny, ...
Bioorganic Chemistry 86, 598-608, 2019
SLC-0111 enaminone analogs, 3/4-(3-aryl-3-oxopropenyl) aminobenzenesulfonamides, as novel selective subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform IX
WM Eldehna, MF Abo-Ashour, E Berrino, D Vullo, HA Ghabbour, ...
Bioorganic chemistry 83, 549-558, 2019
Synthesis, in vitro biological activities and in silico study of dihydropyrimidines derivatives
A Barakat, MS Islam, AM Al-Majid, HA Ghabbour, HK Fun, K Javed, ...
Bioorganic & Medicinal Chemistry 23 (20), 6740-6748, 2015
Synthesis, crystal structure, hirshfeld surface analysis, DFT calculations, anti-diabetic activity and molecular docking studies of (E)-N’-(5-bromo-2-hydroxybenzylidene …
K Karrouchi, S Fettach, MM Jotani, A Sagaama, S Radi, HA Ghabbour, ...
Journal of Molecular Structure 1221, 128800, 2020
Sickle cell disease subphenotypes in patients from Southwestern Province of Saudi Arabia
A Alsultan, A Aleem, H Ghabbour, FH AlGahtani, A Al-Shehri, ME Osman, ...
Journal of Pediatric Hematology/Oncology 34 (2), 79, 2012
Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells
RSM Ismail, SM Abou-Seri, WM Eldehna, NSM Ismail, SM Elgazwi, ...
European Journal of Medicinal Chemistry 155, 782-796, 2018
New pyrazole-hydrazone derivatives: X-ray analysis, molecular structure investigation via density functional theory (DFT) and their high in-situ catecholase activity
K Karrouchi, EB Yousfi, NK Sebbar, Y Ramli, J Taoufik, Y Ouzidan, ...
International journal of molecular sciences 18 (11), 2215, 2017
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