| Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents KH Huang, JM Veal, RP Fadden, JW Rice, J Eaves, JP Strachan, ... Journal of medicinal chemistry 52 (14), 4288-4305, 2009 | 217 | 2009 |
| Rapamycin alkoxyesters PF Hughes US Patent 5,233,036, 1993 | 180 | 1993 |
| Rapamycin analogs as immunosuppressants and antifungals PF Hughes, JH Musser US Patent 5,138,051, 1992 | 176 | 1992 |
| Total synthesis of (-)-balanol JW Lampe, PF Hughes, CK Biggers, SH Smith, H Hu The Journal of Organic Chemistry 59 (18), 5147-5148, 1994 | 160 | 1994 |
| Fasnall, a selective FASN inhibitor, shows potent anti-tumor activity in the MMTV-Neu model of HER2+ breast cancer Y Alwarawrah, P Hughes, D Loiselle, DA Carlson, DB Darr, JL Jordan, ... Cell chemical biology 23 (6), 678-688, 2016 | 144 | 2016 |
| Takinib, a selective TAK1 inhibitor, broadens the therapeutic efficacy of TNF-α inhibition for cancer and autoimmune disease J Totzke, D Gurbani, R Raphemot, PF Hughes, K Bodoor, DA Carlson, ... Cell chemical biology 24 (8), 1029-1039. e7, 2017 | 130 | 2017 |
| Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90 P Fadden, KH Huang, JM Veal, PM Steed, AF Barabasz, B Foley, M Hu, ... Chemistry & biology 17 (7), 686-694, 2010 | 98 | 2010 |
| Two chiral syntheses of threo-3-hydroxylsine PF Hughes, SH Smith, JT Olson The Journal of Organic Chemistry 59 (19), 5799-5802, 1994 | 75 | 1994 |
| Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70 MK Howe, K Bodoor, DA Carlson, PF Hughes, Y Alwarawrah, DR Loiselle, ... Chemistry & biology 21 (12), 1648-1659, 2014 | 71 | 2014 |
| Discovery and structure− activity relationships of novel piperidine inhibitors of farnesyltransferase S Nara, R Tanaka, J Eishima, M Hara, Y Takahashi, S Otaki, ... Journal of medicinal chemistry 46 (12), 2467-2473, 2003 | 71 | 2003 |
| Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits JW Lampe, CK Biggers, JM Defauw, RJ Foglesong, SE Hall, JM Heerding, ... Journal of medicinal chemistry 45 (12), 2624-2643, 2002 | 68 | 2002 |
| Synthesis of 2, 4-methanoproline P Hughes, M Martin, J Clardy Tetrahedron Letters 21 (48), 4579-4580, 1980 | 68 | 1980 |
| Oxepane isomers of rapamycin useful as immunosuppressive agents PF Hughes US Patent 5,221,740, 1993 | 67 | 1993 |
| Conformational properties of 2, 4-methanoproline (2-carboxy-2, 4-methanopyrrolidine) in peptides: determination of preferred peptide bond conformation in aqueous solution by … GT Montelione, P Hughes, J Clardy, HA Scheraga Journal of the American Chemical Society 108 (21), 6765-6773, 1986 | 66 | 1986 |
| Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells JJ Barrott, PF Hughes, T Osada, XY Yang, ZC Hartman, DR Loiselle, ... Chemistry & biology 20 (9), 1187-1197, 2013 | 65 | 2013 |
| Total synthesis of cyclobutane amino acids from Atelia herbert smithii P Hughes, J Clardy The Journal of Organic Chemistry 53 (20), 4793-4796, 1988 | 64 | 1988 |
| Total synthesis of 3 (S)-carboxy-4 (S)-hydroxy-2, 3, 4, 5-tetrahydropyridazine, an unusual amino acid constituent of luzopeptin A P Hughes, J Clardy The Journal of Organic Chemistry 54 (14), 3260-3264, 1989 | 63 | 1989 |
| The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding MR Woodford, DM Dunn, AR Blanden, D Capriotti, D Loiselle, ... Nature communications 7 (1), 12037, 2016 | 62 | 2016 |
| Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor DA Carlson, AS Franke, DH Weitzel, BL Speer, PF Hughes, L Hagerty, ... ACS chemical biology 8 (12), 2715-2723, 2013 | 57 | 2013 |
| Rapamycin analog as immunosuppressant PF Hughes, JH Musser US Patent 5,202,332, 1993 | 57 | 1993 |
Herbert Kim LyerlyProfessor, Duke UniversityVerified email at mc.duke.edu
