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Francesco Antonio Aprile
Francesco Antonio Aprile
Department of Chemistry, Imperial College London
Verified email at imperial.ac.uk
Title
Cited by
Cited by
Year
Direct observation of the interconversion of normal and toxic forms of α-synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ...
Cell 149 (5), 1048-1059, 2012
7582012
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015
3862015
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
Journal of molecular biology 427 (2), 478-490, 2015
2732015
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
2192017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
1042017
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ...
Nature communications 10 (1), 1-11, 2019
1012019
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
P Sormanni, FA Aprile, M Vendruscolo
Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015
1012015
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, ...
Journal of molecular biology 425 (14), 2397-2411, 2013
932013
Targeting amyloid aggregation: an overview of strategies and mechanisms
S Giorgetti, C Greco, P Tortora, FA Aprile
International journal of molecular sciences 19 (9), 2677, 2018
812018
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, ...
PLoS One 8 (6), e67961, 2013
812013
Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, ...
ACS nano 10 (1), 333-341, 2016
772016
Third generation antibody discovery methods: in silico rational design
P Sormanni, FA Aprile, M Vendruscolo
Chemical Society Reviews 47 (24), 9137-9157, 2018
712018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
652018
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
FA Aprile, E Källstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
Scientific reports 7 (1), 1-11, 2017
572017
Structure of a low-population binding intermediate in protein-RNA recognition
AN Borkar, MF Bardaro Jr, C Camilloni, FA Aprile, G Varani, ...
Proceedings of the National Academy of Sciences 113 (26), 7171-7176, 2016
522016
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, ...
Acta neuropathologica communications 7 (1), 1-13, 2019
512019
Methods of probing the interactions between small molecules and disordered proteins
GT Heller, FA Aprile, M Vendruscolo
Cellular and Molecular Life Sciences 74 (17), 3225-3243, 2017
492017
Inhibition of α-synuclein fibril elongation by Hsp70 is governed by a kinetic binding competition between α-synuclein species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, ...
Biochemistry 56 (9), 1177-1180, 2017
492017
Sequence specificity in the entropy-driven binding of a small molecule and a disordered peptide
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, ...
Journal of molecular biology 429 (18), 2772-2779, 2017
452017
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ...
Science advances 6 (45), eabb5924, 2020
362020
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