Francesco Antonio Aprile
Francesco Antonio Aprile
Department of Chemistry, Imperial College London
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Direct observation of the interconversion of normal and toxic forms of α-synuclein
N Cremades, SIA Cohen, E Deas, AY Abramov, AY Chen, A Orte, ...
Cell 149 (5), 1048-1059, 2012
Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation
SW Chen, S Drakulic, E Deas, M Ouberai, FA Aprile, R Arranz, S Ness, ...
Proceedings of the National Academy of Sciences 112 (16), E1994-E2003, 2015
The CamSol method of rational design of protein mutants with enhanced solubility
P Sormanni, FA Aprile, M Vendruscolo
Journal of molecular biology 427 (2), 478-490, 2015
A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity
M Perni, C Galvagnion, A Maltsev, G Meisl, MBD Müller, PK Challa, ...
Proceedings of the National Academy of Sciences 114 (6), E1009-E1017, 2017
Selective targeting of primary and secondary nucleation pathways in Aβ42 aggregation using a rational antibody scanning method
FA Aprile, P Sormanni, M Perni, P Arosio, S Linse, TPJ Knowles, ...
Science advances 3 (6), e1700488, 2017
Different soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
S De, DC Wirthensohn, P Flagmeier, C Hughes, FA Aprile, FS Ruggeri, ...
Nature communications 10 (1), 1-11, 2019
Rational design of antibodies targeting specific epitopes within intrinsically disordered proteins
P Sormanni, FA Aprile, M Vendruscolo
Proceedings of the National Academy of Sciences 112 (32), 9902-9907, 2015
Nanobodies raised against monomeric α-synuclein distinguish between fibrils at different maturation stages
T Guilliams, F El-Turk, AK Buell, EM O'Day, FA Aprile, EK Esbjörner, ...
Journal of molecular biology 425 (14), 2397-2411, 2013
Targeting amyloid aggregation: an overview of strategies and mechanisms
S Giorgetti, C Greco, P Tortora, FA Aprile
International journal of molecular sciences 19 (9), 2677, 2018
Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain
FA Aprile, A Dhulesia, F Stengel, C Roodveldt, JLP Benesch, P Tortora, ...
PLoS One 8 (6), e67961, 2013
Microfluidic diffusion analysis of the sizes and interactions of proteins under native solution conditions
P Arosio, T Müller, L Rajah, EV Yates, FA Aprile, Y Zhang, SIA Cohen, ...
ACS nano 10 (1), 333-341, 2016
Third generation antibody discovery methods: in silico rational design
P Sormanni, FA Aprile, M Vendruscolo
Chemical Society Reviews 47 (24), 9137-9157, 2018
Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
M Perni, P Flagmeier, R Limbocker, R Cascella, FA Aprile, C Galvagnion, ...
ACS chemical biology 13 (8), 2308-2319, 2018
The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
FA Aprile, E Källstig, G Limorenko, M Vendruscolo, D Ron, C Hansen
Scientific reports 7 (1), 1-11, 2017
Structure of a low-population binding intermediate in protein-RNA recognition
AN Borkar, MF Bardaro Jr, C Camilloni, FA Aprile, G Varani, ...
Proceedings of the National Academy of Sciences 113 (26), 7171-7176, 2016
Soluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
S De, DR Whiten, FS Ruggeri, C Hughes, M Rodrigues, DI Sideris, ...
Acta neuropathologica communications 7 (1), 1-13, 2019
Methods of probing the interactions between small molecules and disordered proteins
GT Heller, FA Aprile, M Vendruscolo
Cellular and Molecular Life Sciences 74 (17), 3225-3243, 2017
Inhibition of α-synuclein fibril elongation by Hsp70 is governed by a kinetic binding competition between α-synuclein species
FA Aprile, P Arosio, G Fusco, SW Chen, JR Kumita, A Dhulesia, P Tortora, ...
Biochemistry 56 (9), 1177-1180, 2017
Sequence specificity in the entropy-driven binding of a small molecule and a disordered peptide
GT Heller, FA Aprile, M Bonomi, C Camilloni, A De Simone, ...
Journal of molecular biology 429 (18), 2772-2779, 2017
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer’s disease
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, ...
Science advances 6 (45), eabb5924, 2020
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