Amir Al-Khami
Amir Al-Khami
Principal Scientist, Pfizer Cancer Immunology Discovery (CID/RINAT)
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Inhibition of Fatty Acid Oxidation Modulates Immunosuppressive Functions of Myeloid-Derived Suppressor Cells and Enhances Cancer TherapiesInhibition of Fatty Acid Oxidation …
F Hossain, AA Al-Khami, D Wyczechowska, C Hernandez, L Zheng, ...
Cancer immunology research 3 (11), 1236-1247, 2015
l-Arginine Depletion Blunts Antitumor T-cell Responses by Inducing Myeloid-Derived Suppressor CellsSuppression of T-cell Responses by L-Arginine Depletion
M Fletcher, ME Ramirez, RA Sierra, P Raber, P Thevenot, AA Al-Khami, ...
Cancer research 75 (2), 275-283, 2015
Arginine metabolism in myeloid cells shapes innate and adaptive immunity
PC Rodriguez, AC Ochoa, AA Al-Khami
Frontiers in immunology 8, 93, 2017
The stress-response sensor chop regulates the function and accumulation of myeloid-derived suppressor cells in tumors
PT Thevenot, RA Sierra, PL Raber, AA Al-Khami, J Trillo-Tinoco, P Zarreii, ...
Immunity 41 (3), 389-401, 2014
Redox regulation of T-cell function: from molecular mechanisms to significance in human health and disease
P Kesarwani, AK Murali, AA Al-Khami, S Mehrotra
Antioxidants & redox signaling 18 (12), 1497-1534, 2013
Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells
AA Al-Khami, L Zheng, L Del Valle, F Hossain, D Wyczechowska, ...
Oncoimmunology 6 (10), e1344804, 2017
Recovery from cyclophosphamide-induced lymphopenia results in expansion of immature dendritic cells which can mediate enhanced prime-boost vaccination antitumor responses in …
ML Salem, CM Díaz-Montero, AA Al-Khami, SA El-Naggar, O Naga, ...
The Journal of Immunology 182 (4), 2030-2040, 2009
A quantitative increase in regulatory T cells controls development of vitiligo
S Chatterjee, JM Eby, AA Al-Khami, M Soloshchenko, HK Kang, N Kaur, ...
Journal of Investigative Dermatology 134 (5), 1285-1294, 2014
Cyclophosphamide induces dynamic alterations in the host microenvironments resulting in a Flt3 ligand-dependent expansion of dendritic cells
ML Salem, AA Al-Khami, SA El-Naggar, CM Díaz-Montero, Y Chen, ...
The journal of immunology 184 (4), 1737-1747, 2010
Priming of naive CD8+ T cells in the presence of IL-12 selectively enhances the survival of CD8+ CD62Lhi cells and results in superior anti-tumor activity in a tolerogenic …
CM Díaz-Montero, S El Naggar, A Al Khami, R El Naggar, AJ Montero, ...
Cancer Immunology, Immunotherapy 57 (4), 563-572, 2008
A coreceptor-independent transgenic human TCR mediates anti-tumor and anti-self immunity in mice
S Mehrotra, AA Al-Khami, J Klarquist, S Husain, O Naga, JM Eby, ...
The Journal of Immunology 189 (4), 1627-1638, 2012
Energy metabolic pathways control the fate and function of myeloid immune cells
AA Al‐Khami, PC Rodriguez, AC Ochoa
Journal of leukocyte biology 102 (2), 369-380, 2017
Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide
ML Salem, AA Al-Khami, SA El-Nagaar, AAA Zidan, IM Al-Sharkawi, ...
Cellular immunology 276 (1-2), 67-74, 2012
Metabolic reprogramming of myeloid-derived suppressor cells (MDSC) in cancer
AA Al-Khami, PC Rodriguez, AC Ochoa
Oncoimmunology 5 (8), e1200771, 2016
Pro-survival lipid sphingosine-1-phosphate metabolically programs T cells to limit anti-tumor activity
P Chakraborty, SG Vaena, K Thyagarajan, S Chatterjee, A Al-Khami, ...
Cell reports 28 (7), 1879-1893. e7, 2019
T cells expanded in presence of IL-15 exhibit increased antioxidant capacity and innate effector molecules
N Kaur, OS Naga, H Norell, AA Al-Khami, MJ Scheffel, NG Chakraborty, ...
Cytokine 55 (2), 307-317, 2011
Promoting Thiol Expression Increases the Durability of Antitumor T-cell FunctionsAntioxidant Capacity in T-cell Subsets
P Kesarwani, AA Al-Khami, G Scurti, K Thyagarajan, N Kaur, S Husain, ...
Cancer research 74 (21), 6036-6047, 2014
PARP inhibition by olaparib or gene knockout blocks asthma-like manifestation in mice by modulating CD4+ T cell function
MA Ghonim, K Pyakurel, SV Ibba, AA Al-Khami, J Wang, P Rodriguez, ...
Journal of Translational Medicine 13 (1), 1-12, 2015
PARP is activated in human asthma and its inhibition by olaparib blocks house dust mite-induced disease in mice
MA Ghonim, K Pyakurel, SV Ibba, J Wang, P Rodriguez, AA Al-Khami, ...
Clinical Science 129 (11), 951-962, 2015
Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target
AA Al‐Khami, MA Ghonim, L Del Valle, SV Ibba, L Zheng, K Pyakurel, ...
Clinical & Experimental Allergy 47 (9), 1170-1184, 2017
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