Giovanni Capranico
Giovanni Capranico
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Different patterns of gene expression of topoisomerase II isoforms in differentiated tissues during murine development
G Capranico, S Tinelli, CA Austin, ML Fisher, F Zunino
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1132 (1 …, 1992
DNA topoisomerase II as the primary target of anti-tumor anthracyclines.
F Zunino, G Capranico
Anti-cancer drug design 5 (4), 307-317, 1990
Anthracyclines: selected new developments
M Binaschi, M Bigioni, A Cipollone, C Rossi, C Goso, CA Maggi, ...
Current Medicinal Chemistry-Anti-Cancer Agents 1 (2), 113-130, 2001
Local sequence requirements for DNA cleavage by mammalian topoisomerase II in the presence of doxorubicin
G Capranico, KW Kohn, Y Pommier
Nucleic acids research 18 (22), 6611-6619, 1990
Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin.
C Jaxel, G Capranico, D Kerrigan, KW Kohn, Y Pommier
Journal of Biological Chemistry 266 (30), 20418-20423, 1991
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
A De Magis, SG Manzo, M Russo, J Marinello, R Morigi, O Sordet, ...
Proceedings of the National Academy of Sciences 116 (3), 816-825, 2019
In hepatocellular carcinoma miR‐519d is up‐regulated by p53 and DNA hypomethylation and targets CDKN1A/p21, PTEN, AKT3 and TIMP2
F Fornari, M Milazzo, P Chieco, M Negrini, E Marasco, G Capranico, ...
The Journal of pathology 227 (3), 275-285, 2012
Anthracyclines as topoisomerase II poisons: from early studies to new perspectives
J Marinello, M Delcuratolo, G Capranico
International journal of molecular sciences 19 (11), 3480, 2018
Sequence-selective topoisomerase II inhibition by anthracycline derivatives in SV40 DNA: relationship with DNA binding affinity and cytotoxicity
G Capranico, F Zunino, KW Kohn, Y Pommier
Biochemistry 29 (2), 562-569, 1990
Local base sequence preferences for DNA cleavage by mammalian topoisomerase II in the presence of amsacrine or teniposide
Y Pommier, G Capranico, A Orr, KW Kohn
Nucleic acids research 19 (21), 5973-5980, 1991
Effects of morpholinyl doxorubicins, doxorubicin, and actinomycin D on mammalian DNA topoisomerases I and II.
K Wassermann, J Markovits, C Jaxel, G Capranico, KW Kohn, Y Pommier
Molecular pharmacology 38 (1), 38-45, 1990
DNA sequence selectivity of topoisomerases and topoisomerase poisons
G Capranico, M Binaschi
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression 1400 (1-3 …, 1998
Multidrug sensitivity phenotype of human lung cancer cells associated with topoisomerase II expression
G Giaccone, AF Gazdar, H Beck, F Zunino, G Capranico
Cancer research 52 (7), 1666-1674, 1992
DNA Topoisomerase I differentially modulates R-loops across the human genome
SG Manzo, SR Hartono, LA Sanz, J Marinello, S De Biasi, A Cossarizza, ...
Genome biology 19, 1-18, 2018
A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II poisons
G Capranico, M Binaschi, ME Borgnetto, F Zunino, M Palumbo
Trends in Pharmacological Sciences 18 (9), 323-329, 1997
Molecular modelling studies, synthesis and biological activity of a series of novel bisnaphthalimides and their development as new DNA topoisomerase II inhibitors
R Filosa, A Peduto, S Di Micco, P de Caprariis, M Festa, A Petrella, ...
Bioorganic & Medicinal Chemistry 17 (1), 13-24, 2009
New developments in antitumor anthracyclines
F Arcamone, F Animati, G Capranico, P Lombardi, G Pratesi, S Manzini, ...
Pharmacology & therapeutics 76 (1-3), 117-124, 1997
Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks
A Cristini, G Ricci, S Britton, S Salimbeni, SN Huang, J Marinello, ...
Cell reports 28 (12), 3167-3181. e6, 2019
Relationship between lethal effects and topoisomerase II-mediated double-stranded DNA breaks produced by anthracyclines with different sequence specificity
M Binaschi, G Capranico, L Dal Bo, F Zunino
Molecular pharmacology 51 (6), 1053-1059, 1997
Type i DNA topoisomerases
G Capranico, J Marinello, G Chillemi
Journal of medicinal chemistry 60 (6), 2169-2192, 2017
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