Markos Leggas
Markos Leggas
Professor of Pharmaceutical Sciences, University of Kentucky
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Mrp4 confers resistance to topotecan and protects the brain from chemotherapy
M Leggas, M Adachi, GL Scheffer, D Sun, P Wielinga, G Du, KE Mercer, ...
Molecular and cellular biology 24 (17), 7612-7621, 2004
Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
M Assem, EG Schuetz, M Leggas, D Sun, K Yasuda, G Reid, N Zelcer, ...
Journal of Biological Chemistry 279 (21), 22250-22257, 2004
Gefitinib enhances the antitumor activity and oral bioavailability of irinotecan in mice
CF Stewart, M Leggas, JD Schuetz, JC Panetta, PJ Cheshire, J Peterson, ...
Cancer research 64 (20), 7491-7499, 2004
Stable RNA nanoparticles as potential new generation drugs for cancer therapy
Y Shu, F Pi, A Sharma, M Rajabi, F Haque, D Shu, M Leggas, BM Evers, ...
Advanced drug delivery reviews 66, 74-89, 2014
Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors
VR Adams, M Leggas
Clinical therapeutics 29 (7), 1338-1353, 2007
Development of idarubicin and doxorubicin solid lipid nanoparticles to overcome Pgp-mediated multiple drug resistance in leukemia
P Ma, X Dong, CL Swadley, A Gupte, M Leggas, HC Ledebur, RJ Mumper
Journal of biomedical nanotechnology 5 (2), 151-161, 2009
Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo
M Leggas, JC Panetta, Y Zhuang, JD Schuetz, B Johnston, F Bai, ...
Cancer research 66 (9), 4802-4807, 2006
Biodistribution and bioimaging studies of hybrid paclitaxel nanocrystals: lessons learned of the EPR effect and image-guided drug delivery
CP Hollis, HL Weiss, M Leggas, BM Evers, RA Gemeinhart, T Li
Journal of Controlled Release 172 (1), 12-21, 2013
Topotecan combination chemotherapy in two new rodent models of retinoblastoma
NA Laurie, JK Gray, J Zhang, M Leggas, M Relling, M Egorin, C Stewart, ...
Clinical Cancer Research 11 (20), 7569-7578, 2005
Substrate overlap between Mrp4 and Abcg2/Bcrp affects purine analogue drug cytotoxicity and tissue distribution
K Takenaka, JA Morgan, GL Scheffer, M Adachi, CF Stewart, D Sun, ...
Cancer research 67 (14), 6965-6972, 2007
Morphine versus clonidine for neonatal abstinence syndrome
HS Bada, T Sithisarn, J Gibson, K Garlitz, R Caldwell, G Capilouto, Y Li, ...
Pediatrics 135 (2), e383-e391, 2015
Synthesis and evaluation of a series of benzothiophene acrylonitrile analogs as anticancer agents
NR Penthala, VN Sonar, J Horn, M Leggas, JSKB Yadlapalli, PA Crooks
MedChemComm 4 (7), 1073-1078, 2013
The mathematics of suspensions: Kac walks and asymptotic analyticity
EC Eckstein, JA Goldstein, M Leggas
Proceedings of the Fourth Mississippi State Conference on Difference …, 1999
Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants: optimization and in vitro characterization
X Lu, MD Howard, M Mazik, J Eldridge, JJ Rinehart, M Jay, M Leggas
The AAPS journal 10 (1), 133-140, 2008
Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice
JA Morgan, SB Cheepala, Y Wang, G Neale, M Adachi, D Nachagari, ...
Journal of Biological Chemistry 287 (18), 14456-14466, 2012
Microbore HPLC method with online microdialysis for measurement of topotecan lactone and carboxylate in murine CSF
M Leggas, Y Zhuang, J Welden, Z Self, CM Waters, CF Stewart
Journal of pharmaceutical sciences 93 (9), 2284-2295, 2004
Immunohistochemical detection of multidrug-resistant protein expression in retinoblastoma treated by primary enucleation
MW Wilson, CH Fraga, CE Fuller, C Rodriguez-Galindo, J Mancini, ...
Investigative ophthalmology & visual science 47 (4), 1269-1273, 2006
Relation between Irofulven (MGI-114) systemic exposure and tumor response in human solid tumor xenografts
M Leggas, CF Stewart, MH Woo, M Fouladi, PJ Cheshire, JK Peterson, ...
Clinical cancer research 8 (9), 3000-3007, 2002
Progesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression
M Vore, M Leggas
Molecular pharmacology 73 (3), 613-615, 2008
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691
KA Shaaban, SI Elshahawi, X Wang, J Horn, MK Kharel, M Leggas, ...
Journal of natural products 78 (7), 1723-1729, 2015
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