Reto Horst
Reto Horst
Principal Scientist, Pfizer
Verified email at
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Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR
JJ Liu, R Horst, V Katritch, RC Stevens, K Wüthrich
Science 335 (6072), 1106-1110, 2012
NMR structure reveals intramolecular regulation mechanism for pheromone binding and release
R Horst, F Damberger, P Luginbühl, P Güntert, G Peng, L Nikonova, ...
Proceedings of the National Academy of Sciences 98 (25), 14374-14379, 2001
Allosteric coupling of drug binding and intracellular signaling in the A2A adenosine receptor
MT Eddy, MY Lee, ZG Gao, KL White, T Didenko, R Horst, M Audet, ...
Cell 172 (1-2), 68-80. e12, 2018
NMR characterization of a pH-dependent equilibrium between two folded solution conformations of the pheromone-binding protein from Bombyx mori
F Damberger, L Nikonova, R Horst, G Peng, WS LEAL, K WÜTHRICH
Protein Science 9 (5), 1038-1041, 2000
Structural basis of chaperone–subunit complex recognition by the type 1 pilus assembly platform FimD
M Nishiyama, R Horst, O Eidam, T Herrmann, O Ignatov, M Vetsch, ...
The EMBO journal 24 (12), 2075-2086, 2005
Direct NMR observation of a substrate protein bound to the chaperonin GroEL
R Horst, EB Bertelsen, J Fiaux, G Wider, AL Horwich, K Wüthrich
Proceedings of the National Academy of Sciences 102 (36), 12748-12753, 2005
NMR structure of the unliganded Bombyx mori pheromone-binding protein at physiological pH
D Lee, FF Damberger, G Peng, R Horst, P Güntert, L Nikonova, WS Leal, ...
FEBS letters 531 (2), 314-318, 2002
Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus
P Serrano, MA Johnson, MS Almeida, R Horst, T Herrmann, JS Joseph, ...
Journal of virology 81 (21), 12049-12060, 2007
Fluorine-19 NMR of integral membrane proteins illustrated with studies of GPCRs
T Didenko, JJ Liu, R Horst, RC Stevens, K Wüthrich
Current opinion in structural biology 23 (5), 740-747, 2013
β2‐Adrenergic Receptor Activation by Agonists Studied with 19F NMR Spectroscopy
R Horst, JJ Liu, RC Stevens, K Wüthrich
Angewandte Chemie International Edition 52 (41), 10762-10765, 2013
Folding trajectories of human dihydrofolate reductase inside the GroEL–GroES chaperonin cavity and free in solution
R Horst, WA Fenton, SW Englander, K Wüthrich, AL Horwich
Proceedings of the National Academy of Sciences 104 (52), 20788-20792, 2007
Microscale NMR screening of new detergents for membrane protein structural biology
Q Zhang, R Horst, M Geralt, X Ma, WX Hong, MG Finn, RC Stevens
Journal of the American Chemical Society 130 (23), 7357-7363, 2008
Managing the solvent water polarization to obtain improved NMR spectra of large molecular structures
S Hiller, G Wider, T Etezady-Esfarjani, R Horst, K Wüthrich
Journal of biomolecular NMR 32 (1), 61-70, 2005
Solution‐NMR Characterization of Outer‐Membrane Protein A from E. coli in Lipid Bilayer Nanodiscs and Detergent Micelles
L Sušac, R Horst, K Wüthrich
ChemBioChem 15 (7), 995-1000, 2014
The catalytic mechanism of cyclic GMP‐AMP synthase (cGAS) and implications for innate immunity and inhibition
J Hall, EC Ralph, S Shanker, H Wang, LJ Byrnes, R Horst, J Wong, ...
Protein Science 26 (12), 2367-2380, 2017
Proton–proton Overhauser NMR spectroscopy with polypeptide chains in large structures
R Horst, G Wider, J Fiaux, EB Bertelsen, AL Horwich, K Wüthrich
Proceedings of the National Academy of Sciences 103 (42), 15445-15450, 2006
NMR polypeptide backbone conformation of the E. coli outer membrane protein W
R Horst, P Stanczak, K Wüthrich
Structure 22 (8), 1204-1209, 2014
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
J Schiemer, R Horst, Y Meng, JI Montgomery, Y Xu, X Feng, K Borzilleri, ...
Nature Chemical Biology 17 (2), 152-160, 2021
Translational diffusion of macromolecular assemblies measured using transverse-relaxation-optimized pulsed field gradient NMR
R Horst, AL Horwich, K Wüthrich
Journal of the American Chemical Society 133 (41), 16354-16357, 2011
NMR Characterization of Membrane Protein− Detergent Micelle Solutions by Use of Microcoil Equipment
P Stanczak, R Horst, P Serrano, K Wüthrich
Journal of the American Chemical Society 131 (51), 18450-18456, 2009
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