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Alexander J Dear
Alexander J Dear
Postdoctoral Fellow, SEAS, Harvard University
Verified email at g.harvard.edu
Title
Cited by
Cited by
Year
Dynamics of oligomer populations formed during the aggregation of Alzheimer’s Aβ42 peptide
TCT Michaels, A Šarić, S Curk, K Bernfur, P Arosio, G Meisl, AJ Dear, ...
Nature chemistry 12 (5), 445-451, 2020
2462020
Kinetic diversity of amyloid oligomers
AJ Dear, TCT Michaels, G Meisl, D Klenerman, S Wu, S Perrett, S Linse, ...
Proceedings of the National Academy of Sciences 117 (22), 12087-12094, 2020
1282020
Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants
L Tosatto, MH Horrocks, AJ Dear, TPJ Knowles, M Dalla Serra, ...
Scientific Reports 5 (1), 16696, 2015
1132015
Fast flow microfluidics and single-molecule fluorescence for the rapid characterization of α-synuclein oligomers
MH Horrocks, L Tosatto, AJ Dear, GA Garcia, M Iljina, N Cremades, ...
Analytical chemistry 87 (17), 8818-8826, 2015
952015
Identification of on-and off-pathway oligomers in amyloid fibril formation
AJ Dear, G Meisl, A Šarić, TCT Michaels, M Kjaergaard, S Linse, ...
Chemical science 11 (24), 6236-6247, 2020
712020
Oligomer diversity during the aggregation of the repeat region of tau
M Kjaergaard, AJ Dear, F Kundel, S Qamar, G Meisl, TPJ Knowles, ...
ACS chemical neuroscience 9 (12), 3060-3071, 2018
632018
Electrostatically-guided inhibition of Curli amyloid nucleation by the CsgC-like family of chaperones
JD Taylor, WJ Hawthorne, J Lo, A Dear, N Jain, G Meisl, M Andreasen, ...
Scientific Reports 6 (1), 24656, 2016
62*2016
Quantitative analysis of co-oligomer formation by amyloid-beta peptide isoforms
M Iljina, GA Garcia, AJ Dear, J Flint, P Narayan, TCT Michaels, ...
Scientific reports 6 (1), 28658, 2016
592016
Quantifying co-oligomer formation by α-synuclein
M Iljina, AJ Dear, GA Garcia, S De, L Tosatto, P Flagmeier, DR Whiten, ...
ACS nano 12 (11), 10855-10866, 2018
512018
Direct observation of oligomerization by single molecule fluorescence reveals a multistep aggregation mechanism for the yeast prion protein Ure2
J Yang, AJ Dear, TCT Michaels, CM Dobson, TPJ Knowles, S Wu, ...
Journal of the American Chemical Society 140 (7), 2493-2503, 2018
502018
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
P Flagmeier, S De, TCT Michaels, X Yang, AJ Dear, C Emanuelsson, ...
Nature Structural & Molecular Biology 27 (10), 886-891, 2020
462020
Fluctuations in the kinetics of linear protein self-assembly
TCT Michaels, AJ Dear, JB Kirkegaard, KL Saar, DA Weitz, TPJ Knowles
Physical review letters 116 (25), 258103, 2016
402016
On the mechanism of self-assembly by a hydrogel-forming peptide
GA Braun, BE Ary, AJ Dear, MCH Rohn, AM Payson, DSM Lee, RC Parry, ...
Biomacromolecules 21 (12), 4781-4794, 2020
332020
Fabrication and characterization of reconstituted silk microgels for the storage and release of small molecules
X Liu, Z Toprakcioglu, AJ Dear, A Levin, FS Ruggeri, CG Taylor, M Hu, ...
Macromolecular rapid communications 40 (8), 1800898, 2019
332019
The catalytic nature of protein aggregation
AJ Dear, G Meisl, TCT Michaels, MR Zimmermann, S Linse, TPJ Knowles
The Journal of Chemical Physics 152 (4), 2020
322020
Direct observation of prion protein oligomer formation reveals an aggregation mechanism with multiple conformationally distinct species
JC Sang, JE Lee, AJ Dear, S De, G Meisl, AM Thackray, R Bujdoso, ...
Chemical science 10 (17), 4588-4597, 2019
292019
Amyloid-β peptide 37, 38 and 40 individually and cooperatively inhibit amyloid-β 42 aggregation
GA Braun, AJ Dear, K Sanagavarapu, H Zetterberg, S Linse
Chemical Science 13 (8), 2423-2439, 2022
232022
Stochastic calculus of protein filament formation under spatial confinement
TCT Michaels, AJ Dear, TPJ Knowles
New journal of physics 20 (5), 055007, 2018
222018
In situ kinetic measurements of α-synuclein aggregation reveal large population of short-lived oligomers
E Zurlo, P Kumar, G Meisl, AJ Dear, D Mondal, MMAE Claessens, ...
PLoS One 16 (1), e0245548, 2021
192021
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils
J Yang, AJ Dear, QQ Yao, Z Liu, CM Dobson, TPJ Knowles, S Wu, ...
Nanoscale 12 (36), 18663-18672, 2020
192020
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