Gyanu Lamichhane
Gyanu Lamichhane
Associate Professor, Infectious Diseases, Johns Hopkins University
Verified email at - Homepage
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A postgenomic method for predicting essential genes at subsaturation levels of mutagenesis: application to Mycobacterium tuberculosis
G Lamichhane, M Zignol, NJ Blades, DE Geiman, A Dougherty, J Grosset, ...
Proceedings of the National Academy of Sciences 100 (12), 7213-7218, 2003
Copper resistance is essential for virulence of Mycobacterium tuberculosis
F Wolschendorf, D Ackart, TB Shrestha, L Hascall-Dove, S Nolan, ...
Proceedings of the National Academy of Sciences 108 (4), 1621-1626, 2011
Dormancy Phenotype Displayed by Extracellular Mycobacterium tuberculosis within Artificial Granulomas in Mice
PC Karakousis, T Yoshimatsu, G Lamichhane, SC Woolwine, ...
The Journal of experimental medicine 200 (5), 647-657, 2004
The Mycobacterium tuberculosis protein LdtMt2 is a nonclassical transpeptidase required for virulence and resistance to amoxicillin
R Gupta, M Lavollay, JL Mainardi, M Arthur, WR Bishai, G Lamichhane
Nature medicine 16 (4), 466-469, 2010
Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase
N Agarwal, G Lamichhane, R Gupta, S Nolan, WR Bishai
Nature 460 (7251), 98-102, 2009
Role of the dosR-dosS Two-Component Regulatory System in Mycobacterium tuberculosis Virulence in Three Animal Models
PJ Converse, PC Karakousis, LG Klinkenberg, AK Kesavan, LH Ly, ...
Infection and immunity 77 (3), 1230-1237, 2009
Genetic requirements for the survival of tubercle bacilli in primates
NK Dutta, S Mehra, PJ Didier, CJ Roy, LA Doyle, X Alvarez, M Ratterree, ...
The Journal of infectious diseases 201 (11), 1743-1752, 2010
Designer Arrays for Defined Mutant Analysis To Detect Genes Essential for Survival of Mycobacterium tuberculosis in Mouse Lungs
G Lamichhane, S Tyagi, WR Bishai
Infection and immunity 73 (4), 2533-2540, 2005
Mycobacterium tuberculosis Invasion and Traversal across an In Vitro Human Blood-Brain Barrier as a Pathogenic Mechanism for Central Nervous System …
SK Jain, M Paul-Satyaseela, G Lamichhane, KS Kim, WR Bishai
The Journal of infectious diseases 193 (9), 1287-1295, 2006
Carbapenems and rifampin exhibit synergy against Mycobacterium tuberculosis and Mycobacterium abscessus
A Kaushik, N Makkar, P Pandey, N Parrish, U Singh, G Lamichhane
Antimicrobial agents and chemotherapy 59 (10), 6561-6567, 2015
Novel targets in M. tuberculosis: search for new drugs
G Lamichhane
Trends in molecular medicine 17 (1), 25-33, 2011
Targeting the Cell Wall of Mycobacterium tuberculosis: Structure and Mechanism of L, D-Transpeptidase 2
S Erdemli, R Gupta, W Bishai, G Lamichhane, L Amzel, M Bianchet
Structure 20 (12), 2013-15, 2012
Non-classical transpeptidases yield insight into new antibacterials
P Kumar, A Kaushik, EP Lloyd, SG Li, R Mattoo, NC Ammerman, DT Bell, ...
Nature chemical biology 13 (1), 54-61, 2017
Nonclassical transpeptidases of Mycobacterium tuberculosis alter cell size, morphology, the cytosolic matrix, protein localization, virulence, and resistance to β-lactams
MK Schoonmaker, WR Bishai, G Lamichhane
Journal of bacteriology 196 (7), 1394-1402, 2014
Drug resistance mechanisms and novel drug targets for tuberculosis therapy
MM Islam, HMA Hameed, J Mugweru, C Chhotaray, C Wang, Y Tan, J Liu, ...
Journal of genetics and genomics 44 (1), 21-37, 2017
Murine Model to Study the Invasion and Survival of Mycobacterium tuberculosis in the Central Nervous System
NA Be, G Lamichhane, J Grosset, S Tyagi, QJ Cheng, KS Kim, WR Bishai, ...
The Journal of infectious diseases 198 (10), 1520-1528, 2008
Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development
GL Moraes, GC Gomes, PRM De Sousa, CN Alves, T Govender, ...
Tuberculosis 95 (2), 95-111, 2015
Methionine aminopeptidases from Mycobacterium tuberculosis as novel antimycobacterial targets
O Olaleye, TR Raghunand, S Bhat, J He, S Tyagi, G Lamichhane, P Gu, ...
Chemistry & biology 17 (1), 86-97, 2010
Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase
RJ Dey, B Dey, Y Zheng, LS Cheung, J Zhou, D Sayre, P Kumar, H Guo, ...
Nature chemical biology 13 (2), 210-217, 2017
Essential metabolites of M. tuberculosis and their Mimics
G Lamichhane, JS Freundlich, S Ekins, N Wickramaratne, ST Nolan, ...
mBio 2 (1), e00301-10, 2011
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