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Chris Ulens
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Functional heteromerization of HCN1 and HCN2 pacemaker channels
C Ulens, J Tytgat
Journal of Biological Chemistry 276 (9), 6069-6072, 2001
2672001
Structural determinants of selective α-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP
C Ulens, RC Hogg, PH Celie, D Bertrand, V Tsetlin, AB Smit, TK Sixma
Proceedings of the National Academy of Sciences 103 (10), 3615-3620, 2006
2562006
AChBP‐targeted α‐conotoxin correlates distinct binding orientations with nAChR subtype selectivity
S Dutertre, C Ulens, R Büttner, A Fish, R van Elk, Y Kendel, G Hopping, ...
The EMBO journal 26 (16), 3858-3867, 2007
1942007
Structural insights into Cys-loop receptor function and ligand recognition
M Nys, D Kesters, C Ulens
Biochemical pharmacology 86 (8), 1042-1053, 2013
1462013
Pentameric ligand-gated ion channel ELIC is activated by GABA and modulated by benzodiazepines
R Spurny, J Ramerstorfer, K Price, M Brams, M Ernst, H Nury, M Verheij, ...
Proceedings of the National Academy of Sciences 109 (44), E3028-E3034, 2012
1382012
Regulation of hyperpolarization-activated HCN channels by cAMP through a gating switch in binding domain symmetry
C Ulens, SA Siegelbaum
Neuron 40 (5), 959-970, 2003
1212003
A Structural and Mutagenic Blueprint for Molecular Recognition of Strychnine and d-Tubocurarine by Different Cys-Loop Receptors
M Brams, A Pandya, D Kuzmin, R Van Elk, L Krijnen, JL Yakel, V Tsetlin, ...
PLoS biology 9 (3), e1001034, 2011
1162011
Use of acetylcholine binding protein in the search for novel α7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis
C Ulens, A Akdemir, A Jongejan, R van Elk, S Bertrand, A Perrakis, ...
Journal of medicinal chemistry 52 (8), 2372-2383, 2009
1122009
Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor
R Spurny, S Debaveye, A Farinha, K Veys, AM Vos, T Gossas, J Atack, ...
Proceedings of the National Academy of Sciences 112 (19), E2543-E2552, 2015
1052015
Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC)
R Spurny, B Billen, RJ Howard, M Brams, S Debaveye, KL Price, ...
Journal of Biological Chemistry 288 (12), 8355-8364, 2013
932013
A novel conotoxin from Conus betulinus, κ-BtX, unique in cysteine pattern and in function as a specific BK channel modulator
CX Fan, XK Chen, C Zhang, LX Wang, KL Duan, LL He, Y Cao, SY Liu, ...
Journal of Biological Chemistry 278 (15), 12624-12633, 2003
932003
Structural basis of ligand recognition in 5‐HT3 receptors
D Kesters, AJ Thompson, M Brams, R Van Elk, R Spurny, M Geitmann, ...
EMBO reports 14 (1), 49-56, 2013
842013
Structure of NPP1, an ectonucleotide pyrophosphatase/phosphodiesterase involved in tissue calcification
S Jansen, A Perrakis, C Ulens, C Winkler, M Andries, RP Joosten, ...
Structure 20 (11), 1948-1959, 2012
802012
Molecular actions of smoking cessation drugs at α4β2 nicotinic receptors defined in crystal structures of a homologous binding protein
B Billen, R Spurny, M Brams, R van Elk, S Valera-Kummer, JL Yakel, ...
Proceedings of the National Academy of Sciences 109 (23), 9173-9178, 2012
802012
Two new scorpion toxins that target voltage-gated Ca2+ and Na+ channels
T Olamendi-Portugal, BI García, I López-González, J Van Der Walt, ...
Biochemical and biophysical research communications 299 (4), 562-568, 2002
802002
Crystal structures of a cysteine-modified mutant in loop D of acetylcholine-binding protein
M Brams, EA Gay, JC Sáez, A Guskov, R van Elk, RC van der Schors, ...
Journal of Biological Chemistry 286 (6), 4420-4428, 2011
572011
Morphine-6β-glucuronide and morphine-3-glucuronide, opioid receptor agonists with different potencies
C Ulens, L Baker, A Ratka, D Waumans, J Tytgat
Biochemical pharmacology 62 (9), 1273-1282, 2001
542001
Structural hot spots for the solubility of globular proteins
A Ganesan, A Siekierska, J Beerten, M Brams, J Van Durme, G De Baets, ...
Nature communications 7 (1), 1-15, 2016
512016
Family of prokaryote cyclic nucleotide-modulated ion channels
M Brams, J Kusch, R Spurny, K Benndorf, C Ulens
Proceedings of the National Academy of Sciences 111 (21), 7855-7860, 2014
442014
Norpropoxyphene-induced cardiotoxicity is associated with changes in ion-selectivity and gating of HERG currents
C Ulens, P Daenens, J Tytgat
Cardiovascular research 44 (3), 568-578, 1999
421999
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