Philip Hinchliffe
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Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus
LA Sazanov, P Hinchliffe
Science 311 (5766), 1430-1436, 2006
β-Lactamases and β-lactamase inhibitors in the 21st century
CL Tooke, P Hinchliffe, EC Bragginton, CK Colenso, VHA Hirvonen, ...
Journal of molecular biology 431 (18), 3472-3500, 2019
Organization of iron-sulfur clusters in respiratory complex I
P Hinchliffe, LA Sazanov
Science 309 (5735), 771-774, 2005
Bicyclic Boronate VNRX-5133 Inhibits Metallo-and Serine-β-Lactamases
A Krajnc, J Brem, P Hinchliffe, K Calvopiña, TD Panduwawala, PA Lang, ...
Journal of medicinal chemistry 62 (18), 8544-8556, 2019
Balancing mcr-1 expression and bacterial survival is a delicate equilibrium between essential cellular defence mechanisms
Q Yang, M Li, OB Spiller, DO Andrey, P Hinchliffe, H Li, C MacLean, ...
Nature Communications 8 (1), 2054, 2017
Cross-class metallo-β-lactamase inhibition by bisthiazolidines reveals multiple binding modes
P Hinchliffe, MM González, MF Mojica, JM González, V Castillo, C Saiz, ...
Proceedings of the National Academy of Sciences 113 (26), E3745-E3754, 2016
Insights into the Mechanistic Basis of Plasmid-Mediated Colistin Resistance from Crystal Structures of the Catalytic Domain of MCR-1
P Hinchliffe, QE Yang, E Portal, T Young, H Li, CL Tooke, MJ Carvalho, ...
Scientific reports 7, 39392, 2017
Bisthiazolidines: a substrate-mimicking scaffold as an inhibitor of the NDM-1 carbapenemase
MM González, M Kosmopoulou, MF Mojica, V Castillo, P Hinchliffe, ...
ACS Infectious Diseases 1 (11), 544-554, 2015
Structure and operation of bacterial tripartite pumps
P Hinchliffe, MF Symmons, C Hughes, V Koronakis
Annual review of microbiology 67, 221-242, 2013
Structures of sequential open states in a symmetrical opening transition of the TolC exit duct
XY Pei, P Hinchliffe, MF Symmons, E Koronakis, R Benz, C Hughes, ...
Proceedings of the National Academy of Sciences 108 (5), 2112-2117, 2011
Identification of a novel subunit of respiratory complex I from Thermus thermophilus
P Hinchliffe, J Carroll, LA Sazanov
Biochemistry 45 (14), 4413-4420, 2006
Structural and kinetic studies of the potent inhibition of metallo-β-lactamases by 6-phosphonomethylpyridine-2-carboxylates
P Hinchliffe, CA Tanner, AP Krismanich, G Labbé, VJ Goodfellow, ...
Biochemistry 57 (12), 1880-1892, 2018
Structure of the periplasmic adaptor protein from a major facilitator superfamily (MFS) multidrug efflux pump
P Hinchliffe, NP Greene, NG Paterson, A Crow, C Hughes, V Koronakis
FEBS letters 588 (17), 3147-3153, 2014
Molecular basis of class A β-lactamase inhibition by relebactam
CL Tooke, P Hinchliffe, PA Lang, AJ Mulholland, J Brem, CJ Schofield, ...
Antimicrobial agents and chemotherapy 63 (10), 10.1128/aac. 00564-19, 2019
Structural/mechanistic insights into the efficacy of nonclassical β‐lactamase inhibitors against extensively drug resistant Stenotrophomonas maltophilia clinical isolates
K Calvopiña, P Hinchliffe, J Brem, KJ Heesom, S Johnson, R Cain, ...
Molecular Microbiology 106 (3), 492-504, 2017
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors
J Brem, T Panduwawala, JU Hansen, J Hewitt, E Liepins, P Donets, ...
Nature Chemistry 14 (1), 15-24, 2022
Profiling interactions of vaborbactam with metallo-β-lactamases
GW Langley, R Cain, JM Tyrrell, P Hinchliffe, K Calvopiña, CL Tooke, ...
Bioorganic & medicinal chemistry letters 29 (15), 1981-1984, 2019
Discovery of New and Potent InhA Inhibitors as Antituberculosis Agents: Structure-Based Virtual Screening Validated by Biological Assays and X-ray Crystallography
P Kamsri, C Hanwarinroj, N Phusi, T Pornprom, K Chayajarus, ...
Journal of Chemical Information and Modeling 60 (1), 226-234, 2019
Mechanistic Insights into β-Lactamase-Catalysed Carbapenem Degradation Through Product Characterisation.
CT Lohans, EI Freeman, EV Groesen, CL Tooke, P Hinchliffe, J Spencer, ...
Scientific reports 9 (1), 13608-13608, 2019
Crystal structures of VIM‐1 complexes explain active site heterogeneity in VIM‐class metallo‐β‐lactamases
R Salimraj, P Hinchliffe, M Kosmopoulou, JM Tyrrell, J Brem, ...
The FEBS journal 286 (1), 169-183, 2019
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