Eddy Arnold
Eddy Arnold
Board of Governors and Distinguished Professor of Chemistry and Chemical Biology, Rutgers University
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Cited by
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Structure of a human common cold virus and functional relationship to other picornaviruses.
MG Rossmann, E Arnold, JW Erickson, EA Frankenberger, JP Griffith, ...
Nature 317 (6033), 145, 1985
Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA
A Jacobo-Molina, J Ding, RG Nanni, AD Clark, X Lu, C Tantillo, ...
Proceedings of the National Academy of Sciences 90 (13), 6320, 1993
Isolation and structure of bryostatin 1
GR Pettit, CL Herald, DL Doubek, DL Herald, E Arnold, J Clardy
Journal of the American Chemical Society 104 (24), 6846-6848, 1982
Locations of Anti-AIDS Drug Binding Sites and Resistance Mutations in the Three-dimensional Structure of HIV-1 Reverse Transcriptase:: Implications for Mechanisms of Drug…
C Tantillo, J Ding, A Jacobo-Molina, RG Nanni, PL Boyer, SH Hughes, ...
Journal of molecular biology 243 (3), 369-387, 1994
Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition
SG Sarafianos, B Marchand, K Das, DM Himmel, MA Parniak, SH Hughes, ...
Journal of molecular biology 385 (3), 693-713, 2009
Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that…
K Das, AD Clark, PJ Lewi, J Heeres, MR De Jonge, LMH Koymans, ...
Journal of medicinal chemistry 47 (10), 2550-2560, 2004
The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating
TJ Smith, MJ Kremer, M Luo, G Vriend, E Arnold, G Kamer, MG Rossmann, ...
Science 233 (4770), 1286, 1986
Castanospermine, a 1, 6, 7, 8-tetrahydroxyoctahydroindolizine alkaloid, from seeds of Castanospermum australe
LD Hohenschutz, EA Bell, PJ Jewess, DP Leworthy, RJ Pryce, E Arnold, ...
Phytochemistry 20 (4), 811-814, 1981
Crystal structure of HIV-1 reverse transcriptase in complex with a polypurine tract RNA: DNA
SG Sarafianos, K Das, C Tantillo, AD Clark, J Ding, JM Whitcomb, ...
The EMBO journal 20 (6), 1449-1461, 2001
Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides
T Shirasaka, MF Kavlick, T Ueno, WY Gao, E Kojima, ML Alcaide, ...
Proceedings of the National Academy of Sciences 92 (6), 2398, 1995
Structure of HIV-1 RT/TIBO R 86183 complex reveals similarity in the binding of diverse nonnucleoside inhibitors
J Ding, K Das, H Moereels, L Koymans, K Andries, PAJ Janssen, ...
Nature structural biology 2 (5), 407-415, 1995
Structures of influenza A proteins and insights into antiviral drug targets
K Das, JM Aramini, LC Ma, RM Krug, E Arnold
Nature structural & molecular biology 17 (5), 530-538, 2010
Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody fab fragment at 2…
J Ding, K Das, Y Hsiou, SG Sarafianos, AD Clark, A Jacobo-Molina, ...
Journal of molecular biology 284 (4), 1095-1111, 1998
The atomic structure of Mengo virus at 3.0 A resolution
M Luo, G Vriend, G Kamer, I Minor, E Arnold, MG Rossmann, U Boege, ...
Science 235 (4785), 182, 1987
Structures of human cytosolic NADP-dependent isocitrate dehydrogenase reveal a novel self-regulatory mechanism of activity
X Xu, J Zhao, Z Xu, B Peng, Q Huang, E Arnold, J Ding
Journal of Biological Chemistry 279 (32), 33946-33957, 2004
In Search of a Novel Anti-HIV Drug:  Multidisciplinary Coordination in the Discovery of 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl…
PAJ Janssen, PJ Lewi, E Arnold, F Daeyaert, M De Jonge, J Heeres, ...
Journal of medicinal chemistry 48 (6), 1901-1909, 2005
Structure of unliganded HIV-1 reverse transcriptase at 2.7 resolution: implications of conformational changes for polymerization and inhibition mechanisms
Y Hsiou, J Ding, K Das, AD Clark Jr, SH Hughes, E Arnold
Structure 4 (7), 853-860, 1996
Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids
SG Sarafianos, K Das, AD Clark, J Ding, PL Boyer, SH Hughes, E Arnold
Proceedings of the National Academy of Sciences 96 (18), 10027, 1999
High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: strategic flexibility explains potency against resistance mutations
K Das, JD Bauman, AD Clark Jr, YV Frenkel, PJ Lewi, AJ Shatkin, ...
Proceedings of the National Academy of Sciences 105 (5), 1466-1471, 2008
Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues
DW Ludovici, BL De Corte, MJ Kukla, H Ye, CY Ho, MA Lichtenstein, ...
Bioorganic & Medicinal Chemistry Letters 11 (17), 2235-2239, 2001
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