| Mechanisms of regulation of CXCR4/SDF-1 (CXCL12)–dependent migration and homing in multiple myeloma Y Alsayed, H Ngo, J Runnels, X Leleu, UK Singha, CM Pitsillides, ... Blood 109 (7), 2708-2717, 2007 | 576 | 2007 |
| GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts RM Sterner, R Sakemura, MJ Cox, N Yang, RH Khadka, CL Forsman, ... Blood, The Journal of the American Society of Hematology 133 (7), 697-709, 2019 | 514 | 2019 |
| CXCR4 physically associates with the T cell receptor to signal in T cells A Kumar, TD Humphreys, KN Kremer, PS Bramati, L Bradfield, CE Edgar, ... Immunity 25 (2), 213-224, 2006 | 282 | 2006 |
| Cloning of a Xenopus laevis inwardly rectifying K+ channel subunit that permits GIRK1 expression of IKACh currents in oocytes KE Hedin, NF Lim, DE Clapham Neuron 16 (2), 423-429, 1996 | 216 | 1996 |
| Specificity of receptor-G protein interactions: searching for the structure behind the signal KE Hedin, K Duerson, DE Clapham Cellular signalling 5 (5), 505-518, 1993 | 134 | 1993 |
| Expression of the chemokine receptors CXCR4 and CCR7 and disease progression in B-cell chronic lymphocytic leukemia/small lymphocytic lymphoma IM Ghobrial, ND Bone, MJ Stenson, A Novak, KE Hedin, NE Kay, ... Mayo clinic proceedings 79 (3), 318-325, 2004 | 107 | 2004 |
| PD-1 blunts the function of ovarian tumor–infiltrating dendritic cells by inactivating NF-κB L Karyampudi, P Lamichhane, J Krempski, KR Kalli, MD Behrens, ... Cancer research 76 (2), 239-250, 2016 | 105 | 2016 |
| Distinct role of ZAP-70 and Src homology 2 domain-containing leukocyte protein of 76 kDa in the prolonged activation of extracellular signal-regulated protein kinase by the … KN Kremer, TD Humphreys, A Kumar, NX Qian, KE Hedin The Journal of Immunology 171 (1), 360-367, 2003 | 98 | 2003 |
| Characterization of the CXCR4 signaling in pancreatic cancer cells DD Billadeau, S Chatterjee, P Bramati, R Sreekumar, V Shah, K Hedin, ... Journal of Gastrointestinal Cancer 37, 110-119, 2006 | 93 | 2006 |
| Delta-opioid receptors expressed by Jurkat T cells enhance IL-2 secretion by increasing AP-1 complexes and activity of the NF-AT/AP-1-binding promoter element. KE Hedin, MP Bell, KR Kalli, CJ Huntoon, BM Sharp, DJ McKean Journal of immunology (Baltimore, Md.: 1950) 159 (11), 5431-5440, 1997 | 78 | 1997 |
| CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak KN Kremer, KL Peterson, PA Schneider, XW Meng, H Dai, AD Hess, ... Journal of Biological Chemistry 288 (32), 22899-22914, 2013 | 76 | 2013 |
| Gα13 and Rho mediate endosomal trafficking of CXCR4 into Rab11+ vesicles upon stromal cell-derived factor-1 stimulation A Kumar, KN Kremer, D Dominguez, M Tadi, KE Hedin The Journal of Immunology 186 (2), 951-958, 2011 | 73 | 2011 |
| Gi proteins use a novel βγ-and Ras-independent pathway to activate extracellular signal-regulated kinase and mobilize AP-1 transcription factors in Jurkat T lymphocytes KE Hedin, MP Bell, CJ Huntoon, LM Karnitz, DJ McKean Journal of Biological Chemistry 274 (28), 19992-20001, 1999 | 64 | 1999 |
| Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse J Kim, MJ Shapiro, AO Bamidele, P Gurel, P Thapa, HN Higgs, KE Hedin, ... PloS one 9 (1), e85090, 2014 | 52 | 2014 |
| Stromal cell-derived factor-1 signaling via the CXCR4-TCR heterodimer requires phospholipase C-β3 and phospholipase C-γ1 for distinct cellular responses KN Kremer, IC Clift, AG Miamen, AO Bamidele, NX Qian, TD Humphreys, ... The Journal of Immunology 187 (3), 1440-1447, 2011 | 52 | 2011 |
| Maturation versus death of developing double-positive thymocytes reflects competing effects on Bcl-2 expression and can be regulated by the intensity of CD28 costimulation DJ McKean, CJ Huntoon, MP Bell, X Tai, S Sharrow, KE Hedin, A Conley, ... The Journal of Immunology 166 (5), 3468-3475, 2001 | 50 | 2001 |
| Haplotype-independent costimulation of IL-10 secretion by SDF-1/CXCL12 proceeds via AP-1 binding to the human IL-10 promoter KN Kremer, A Kumar, KE Hedin The Journal of Immunology 178 (3), 1581-1588, 2007 | 49 | 2007 |
| Osteoblasts protect AML cells from SDF‐1‐induced apoptosis KN Kremer, A Dudakovic, ME McGee‐Lawrence, RL Philips, AD Hess, ... Journal of cellular biochemistry 115 (6), 1128-1137, 2014 | 40 | 2014 |
| Chemokines: new, key players in the pathobiology of pancreatic cancer KE Hedin International journal of gastrointestinal cancer 31, 23-29, 2002 | 34 | 2002 |
| GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion BA Dinkel, KN Kremer, MR Rollins, MJ Medlyn, KE Hedin Journal of Biological Chemistry 293 (36), 14022-14039, 2018 | 27 | 2018 |
Irene GhobrialDana-Farber Cancer InstituteVerified email at dfci.harvard.edu
