Robert Geahlen
Robert Geahlen
Distinguished Professor of Medicinal Chemistry, Purdue University
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Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
M Turner, P Joseph Mee, PS Costello, O Williams, AA Price, LP Duddy, ...
Nature 378 (6554), 298-302, 1995
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol.
JM Oliver, DL Burg, BS Wilson, JL McLaughlin, RL Geahlen
Journal of Biological Chemistry 269 (47), 29697-29703, 1994
Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.
JE Hutchcroft, ML Harrison, RL Geahlen
Journal of Biological Chemistry 267 (12), 8613-8619, 1992
Kinase inhibitors from Polygonum cuspidatum
GS Jayatilake, H Jayasuriya, ES Lee, NM Koonchanok, RL Geahlen, ...
Journal of Natural Products 56 (10), 1805-1810, 1993
Cloning and expression of a protein-tyrosine-phosphatase.
KL Guan, RS Haun, SJ Watson, RL Geahlen, JE Dixon
Proceedings of the National Academy of Sciences 87 (4), 1501-1505, 1990
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells.
JE Hutchcroft, RL Geahlen, GG Deanin, JM Oliver
Proceedings of the National Academy of Sciences 89 (19), 9107-9111, 1992
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum
H Jayasuriya, NM Koonchanok, RL Geahlen, JL McLaughlin, CJ Chang
Journal of Natural Products 55 (5), 696-698, 1992
Piceatannol (3, 4, 3′, 5′-tetrahydroxy-trans-stilbene) is a naturally occurring protein-tyrosine kinase inhibitor
RL Geahlen, JL McLaughlin
Biochemical and biophysical research communications 165 (1), 241-245, 1989
Mechanisms of p34cdc2 Regulation
S Atherton-Fessler, LL Parker, RL Geahlen, H Piwnica-Worms
Molecular and cellular biology 13 (3), 1675-1685, 1993
DAP12-mediated signal transduction in natural killer cells: a dominant role for the Syk protein-tyrosine kinase
DW McVicar, LS Taylor, P Gosselin, J Willette-Brown, AI Mikhael, ...
Journal of Biological Chemistry 273 (49), 32934-32942, 1998
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases.
SJ Corey, AL Burkhardt, JB Bolen, RL Geahlen, LS Tkatch, DJ Tweardy
Proceedings of the National Academy of Sciences 91 (11), 4683-4687, 1994
Measuring nanoscale viscoelastic parameters of cells directly from AFM force-displacement curves
YM Efremov, WH Wang, SD Hardy, RL Geahlen, A Raman
Scientific reports 7 (1), 1541, 2017
CD22 associates with the human surface IgM-B-cell antigen receptor complex.
C Leprince, KE Draves, RL Geahlen, JA Ledbetter, EA Clark
Proceedings of the National Academy of Sciences 90 (8), 3236-3240, 1993
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogs
M Cushman, D Nagarathnam, DL Burg, RL Geahlen
Journal of medicinal chemistry 34 (2), 798-806, 1991
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase
JE Hutchcroft, ML Harrison, RL Geahlen
Journal of Biological Chemistry 266 (23), 14846-14849, 1991
Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis
ML Harrison, P Rathinavelu, P Arese, RL Geahlen, PS Low
Journal of biological chemistry 266 (7), 4106-4111, 1991
Getting Syk: spleen tyrosine kinase as a therapeutic target
RL Geahlen
Trends in pharmacological sciences 35 (8), 414-422, 2014
Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogs of piceatannol
K Thakkar, RL Geahlen, M Cushman
Journal of medicinal chemistry 36 (20), 2950-2955, 1993
Syk and pTyr'd: Signaling through the B cell antigen receptor
RL Geahlen
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1793 (7), 1115-1127, 2009
p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals
GL Schieven, JM Kirihara, DL Burg, RL Geahlen, JA Ledbetter
Journal of Biological Chemistry 268 (22), 16688-16692, 1993
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