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Bruno M. Simões
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A detailed mammosphere assay protocol for the quantification of breast stem cell activity
FL Shaw, H Harrison, K Spence, MP Ablett, BM Simões, G Farnie, ...
Journal of mammary gland biology and neoplasia 17, 111-117, 2012
4302012
Sox2 promotes tamoxifen resistance in breast cancer cells
M Piva, G Domenici, O Iriondo, M Rábano, BM Simoes, V Comaills, ...
EMBO molecular medicine 6 (1), 66-79, 2014
3372014
Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells
JK Singh, BM Simões, SJ Howell, G Farnie, RB Clarke
Breast Cancer Research 15, 1-9, 2013
2772013
Targeting CXCR1/2 significantly reduces breast cancer stem cell activity and increases the efficacy of inhibiting HER2 via HER2-dependent and-independent mechanisms
JK Singh, G Farnie, NJ Bundred, BM Simões, A Shergill, G Landberg, ...
Clinical cancer research 19 (3), 643-656, 2013
2402013
Anti-estrogen resistance in human breast tumors is driven by JAG1-NOTCH4-dependent cancer stem cell activity
BM Simoes, CS O’Brien, R Eyre, A Silva, L Yu, A Sarmiento-Castro, ...
Cell reports 12 (12), 1968-1977, 2015
1882015
Effects of estrogen on the proportion of stem cells in the breast
BM Simões, M Piva, O Iriondo, V Comaills, JA López-Ruiz, I Zabalza, ...
Breast cancer research and treatment 129, 23-35, 2011
1402011
A Sox2–Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells
G Domenici, I Aurrekoetxea-Rodríguez, BM Simões, M Rábano, SY Lee, ...
Oncogene 38 (17), 3151-3169, 2019
1282019
Multifunctionalized iron oxide nanoparticles for selective drug delivery to CD44-positive cancer cells
A Aires, SM Ocampo, BM Simões, MJ Rodríguez, JF Cadenas, ...
Nanotechnology 27 (6), 065103, 2016
1242016
Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling
R Eyre, DG Alférez, A Santiago-Gómez, K Spence, JC McConnell, C Hart, ...
Nature communications 10 (1), 5016, 2019
1152019
Oestrogen increases the activity of oestrogen receptor negative breast cancer stem cells through paracrine EGFR and Notch signalling
H Harrison, BM Simões, L Rogerson, SJ Howell, G Landberg, RB Clarke
Breast Cancer Research 15, 1-12, 2013
1072013
Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity
C Giordano, F Chemi, S Panza, I Barone, D Bonofiglio, M Lanzino, ...
Oncotarget 7 (2), 1262, 2016
842016
A role for notch signalling in breast cancer and endocrine resistance
A Acar, BM Simões, RB Clarke, K Brennan
Stem cells international 2016, 2016
802016
Reprogramming of amino acid transporters to support aspartate and glutamate dependency sustains endocrine resistance in breast cancer
M Bacci, N Lorito, L Ippolito, M Ramazzotti, S Luti, S Romagnoli, M Parri, ...
Cell reports 28 (1), 104-118. e8, 2019
792019
Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling
L Yu, Z Fan, S Fang, J Yang, T Gao, BM Simões, R Eyre, W Guo, ...
oncotarget 7 (22), 33055, 2016
762016
FKBPL and its peptide derivatives inhibit endocrine therapy resistant cancer stem cells and breast cancer metastasis by downregulating DLL4 and Notch4
L McClements, S Annett, A Yakkundi, M O’Rourke, A Valentine, ...
BMC cancer 19, 1-14, 2019
522019
Patient-derived mammosphere and xenograft tumour initiation correlates with progression to metastasis
R Eyre, DG Alférez, K Spence, M Kamal, FL Shaw, BM Simões, ...
Journal of mammary gland biology and neoplasia 21, 99-109, 2016
472016
The role of steroid hormones in breast cancer stem cells
BM Simoes, DG Alferez, SJ Howell, RB Clarke
Endocrine-related cancer 22 (6), T177-T186, 2015
462015
Targeting IL-8 signalling to inhibit breast cancer stem cell activity
JK Singh, BM Simoes, RB Clarke, NJ Bundred
Expert Opinion on Therapeutic Targets 17 (11), 1235-1241, 2013
462013
The role of steroid hormones in breast and effects on cancer stem cells
DG Alferez, BM Simões, SJ Howell, RB Clarke
Current stem cell reports 4, 81-94, 2018
452018
Acquired resistance of ER-positive breast cancer to endocrine treatment confers an adaptive sensitivity to TRAIL through posttranslational downregulation of c-FLIP
L Piggott, A Silva, T Robinson, A Santiago-Gómez, BM Simões, M Becker, ...
Clinical Cancer Research 24 (10), 2452-2463, 2018
422018
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Articles 1–20