| Discovery of potent VEGFR-2 inhibitors based on furopyrimidine and thienopyrimidne scaffolds as cancer targeting agents MA Aziz, RAT Serya, DS Lasheen, AK Abdel-Aziz, A Esmat, AM Mansour, ... Scientific reports 6 (1), 24460, 2016 | 141 | 2016 |
| Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer HM Hesham, DS Lasheen, KAM Abouzid Medicinal Research Reviews 38 (6), 2058-2109, 2018 | 130 | 2018 |
| Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer FM Elmenier, DS Lasheen, KAM Abouzid European journal of medicinal chemistry 183, 111718, 2019 | 93 | 2019 |
| How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors SN Milik, DS Lasheen, RAT Serya, KAM Abouzid European Journal of Medicinal Chemistry 142, 131-151, 2017 | 55 | 2017 |
| Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII DA Ibrahim, DS Lasheen, MY Zaky, AW Ibrahim, D Vullo, M Ceruso, ... Bioorganic & medicinal chemistry 23 (15), 4989-4999, 2015 | 51 | 2015 |
| Surmounting the resistance against EGFR inhibitors through the development of thieno [2, 3-d] pyrimidine-based dual EGFR/HER2 inhibitors SN Milik, AK Abdel-Aziz, DS Lasheen, RAT Serya, S Minucci, ... European Journal of Medicinal Chemistry 155, 316-336, 2018 | 49 | 2018 |
| Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives S Mowafy, A Galanis, ZM Doctor, RM Paranal, DS Lasheen, NA Farag, ... Bioorganic & medicinal chemistry 24 (16), 3501-3512, 2016 | 44 | 2016 |
| Covalent EGFR inhibitors: binding mechanisms, synthetic approaches, and clinical profiles M Hossam, DS Lasheen, KAM Abouzid Archiv der Pharmazie 349 (8), 573-593, 2016 | 40 | 2016 |
| Click and Release: SO2 Prodrugs with Tunable Release Rates X Ji, EM El-Labbad, K Ji, DS Lasheen, RAT Serya, KA Abouzid, B Wang Organic letters 19 (4), 818-821, 2017 | 36 | 2017 |
| Discovery of anilino-furo [2, 3-d] pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity M Hossam, DS Lasheen, NSM Ismail, A Esmat, AM Mansour, ANB Singab, ... European Journal of Medicinal Chemistry 144, 330-348, 2018 | 35 | 2018 |
| 3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: design, synthesis and biological evaluation MK Sobhy, S Mowafy, DS Lasheen, NA Farag, KAM Abouzid Bioorganic chemistry 89, 102988, 2019 | 34 | 2019 |
| Identification of new pyrrolo [2, 3-d] pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling M Adel, RAT Serya, DS Lasheen, KAM Abouzid Bioorganic chemistry 81, 612-629, 2018 | 32 | 2018 |
| Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition S Elmeligie, AM Aboul-Magd, DS Lasheen, TM Ibrahim, TM Abdelghany, ... Journal of Enzyme Inhibition and Medicinal Chemistry 34 (1), 1347-1367, 2019 | 31 | 2019 |
| Furo [2, 3-d] pyrimidine based derivatives as kinase inhibitors and anticancer agents MA Aziz, RAT Serya, DS Lasheen, KAM Abouzid Future Journal of Pharmaceutical Sciences 2 (1), 1-8, 2016 | 27 | 2016 |
| Thiazolo [4, 5-d] pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study MA Ewida, DA Abou El Ella, DS Lasheen, HA Ewida, YI El-Gazzar, ... Bioorganic chemistry 74, 228-237, 2017 | 26 | 2017 |
| Imidazo [2′, 1′: 2, 3] thiazolo [4, 5-d] pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study MA Ewida, DA Abou El Ella, DS Lasheen, HA Ewida, YI El-Gazzar, ... Bioorganic Chemistry 80, 11-23, 2018 | 25 | 2018 |
| Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors SR Abd El Hadi, DS Lasheen, DH Soliman, EZ Elrazaz, KAM Abouzid Bioorganic Chemistry 101, 103961, 2020 | 22 | 2020 |
| Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies AH Eldeeb, MF Abo-Ashour, A Angeli, A Bonardi, DS Lasheen, ... European Journal of Medicinal Chemistry 221, 113486, 2021 | 21 | 2021 |
| Design and Synthesis of 4‐Anilinothieno[2,3‐d]pyrimidine‐Based Compounds as Dual EGFR/HER‐2 Inhibitors SR Abd El Hadi, DS Lasheen, MA Hassan, KAM Abouzid Archiv der Pharmazie 349 (11), 827-847, 2016 | 21 | 2016 |
| Pyrrolopyrimidine, a multifaceted scaffold in cancer targeted therapy M Adel, RAT Serya, DS Lasheen, KAM Abouzid Drug research 68 (09), 485-498, 2018 | 13 | 2018 |
Khaled Abouzidprofessor of pharmaceutical chemistryVerified email at pharma.asu.edu.eg
